Dissertação
Endocanabinoide no condicionamento contextual a drogas de abuso: uma revisão de literatura
Fecha
2020-04-14Autor
Aline de Castro Santos
Institución
Resumen
Endocannabinoids are lipid mediators that interact with cannabinoid receptors, that recognize Δ9
tetrahydrocannabinol, the main psychoactive component of Cannabis sativa. Drugs of abuse
produce similar changes in specific brain pathways, including reward circuits. The
endocannabinoid system modulates these pathways and has been studied as a crucial component
of this circuit underlying drug effects. A model frequently used for the study of rewarding effects
of drugs is the conditioned place preference (CPP). This review presents data and discusses the
involvement of the endocannabinoid system in CPP induced by drugs such as cocaine, alcohol,
opioids, nicotine and amphetamine. The endocannabinoid system is involved in the effects of
drugs of abuse, in which CB1 receptor antagonists and CB2 receptors agonists reduce the
rewardign effects induced by certain drugs.