dc.contributorRossimiriam Pereira de Freitas
dc.contributorRosemeire Brondi Alves
dc.contributorMarcelo Henrique dos Santos
dc.contributorRobson Ricardo Teixeira
dc.contributorRenata Barbosa de Oliveira
dc.contributorHenriete da Silva Vieira
dc.creatorGuilherme Rocha Pereira
dc.date.accessioned2019-08-13T06:35:56Z
dc.date.accessioned2022-10-03T22:43:04Z
dc.date.available2019-08-13T06:35:56Z
dc.date.available2022-10-03T22:43:04Z
dc.date.created2019-08-13T06:35:56Z
dc.date.issued2011-03-04
dc.identifierhttp://hdl.handle.net/1843/SFSA-8FWPNF
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3809047
dc.description.abstractThe new carbon allotrope, the fullerene C60, since its discovery has generated great interest of the scientific community due to its unique properties and growing potential in the fields of materials and biology. However, the low solubility in organic solvents and its tendency togenerate aggregates limited fullerene applications. To minimize these properties, derivatization of fullerene C60 with organic compounds on its surface has being widely used by many research groups. This work was based on the synthesis of fullerene derivates exploiting Bingels cyclopropanation. Among the new synthesized fullerene derivatives,twelve were new, and one of these, made by eleven steps, is a cationic salt with solubility in polar solvents. Synthesis of functionalized glycoconjugated-fullerenes by using the known Click reactionwas explored in this work. Through this reaction, one molecule containing the azide function and other with alkyne functionality could be united to form the 1,2,3-triazol. This way, some monoadduct fullerene derivatives with the alkyne functionality were made to generate a building block. Later, these compounds would be used as starting material to react withother molecules containing the azide functionality. These new monoadduct fullerenes created to be a building block did not react by the Click reaction, probably due to their low solubility in organic solvents. After this, another bisadduct fullerene derivative was synthesized to form a new building block and overcome this issue. This compound turnedout to be a good substrate to the Click reaction, and after reacted with several carbohydrates containing azide functionality, six new fullero-glicoconjugates were made.
dc.publisherUniversidade Federal de Minas Gerais
dc.publisherUFMG
dc.rightsAcesso Aberto
dc.subjectFulerenos
dc.subjectReação click
dc.subjectFulereno-glicoconjugado
dc.titleSíntese de novos derivados fulerênicos explorando a "reação click" e de um derivado C60-catiônico polar
dc.typeTese de Doutorado


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