dc.contributor | Marco Aurelio Lana Peixoto | |
dc.contributor | Dagoberto Callegaro | |
dc.contributor | Jefferson Becker | |
dc.contributor | Edson Samesima Tatsuo | |
dc.contributor | Luciene Chaves Fernandes | |
dc.creator | Livia Edwiges Cirino Talim | |
dc.date.accessioned | 2019-08-12T17:25:37Z | |
dc.date.accessioned | 2022-10-03T22:36:09Z | |
dc.date.available | 2019-08-12T17:25:37Z | |
dc.date.available | 2022-10-03T22:36:09Z | |
dc.date.created | 2019-08-12T17:25:37Z | |
dc.date.issued | 2013-09-13 | |
dc.identifier | http://hdl.handle.net/1843/BUBD-9UHK2G | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3806311 | |
dc.description.abstract | TITLE: Study of Multiple Sclerosis Functional Composite (MSFC) in patients with isolated demyelinating optic neuritis. INTRODUCTION: Isolated idiopathic optic neuritis (IION) is an immune-mediated inflammatory disease of the optic nerve which carries a risk of converting to multiple sclerosis (MS). Although conversion depends on a number of factors, the presence of subclinical abnormalities at brain magnetic resonance imaging at baseline is the strongest predictive factor. OBJECTIVES: To evaluate the Multiple Sclerosis Functional Composity (MSFC) as a tool to identify subclinical neurological abnormalities in patients with IION. PATIENTS AND METHODS: The scores of the MSFC individual component tests and the MSFC Z-Score of 34 patients with unilateral monophasic IION and 34 matched healthy controls were compared. RESULTS: The T25-FW and the 9-HPT scores were significantly lower in IION patients than in Controls (p=0.000 and p=0.003 respectively) whereas the PASAT scores were not different in these groups (p=0.135). Patients with IION had lower Z-Score than Controls (p=0.001). CONCLUSION: MSFC is a valuable tool to identify subclinical functional abnormalities in IION patients. These changes may suggest dissemination of demyelinating lesions in space and turn out to be a predictive factor of MS developing in patients with IION. | |
dc.publisher | Universidade Federal de Minas Gerais | |
dc.publisher | UFMG | |
dc.rights | Acesso Aberto | |
dc.subject | Neurite óptica desmielinizante isolada | |
dc.subject | Teste Auditivo Compassado de Adição Seriada (PASAT) | |
dc.subject | Multiple Sclerosis Functional Composite (MSFC) | |
dc.subject | Teste Cronometrado dos 9 Pinos e Buracos (9-HPT) | |
dc.subject | esclerose múltipla | |
dc.title | Estudo do Multiple Sclerosis Functional Composite (MSFC) em portadores de neurite óptica desmielinizante isolada | |
dc.type | Tese de Doutorado | |