Tese de Doutorado
Ancestralidade genômica como fator predisponente para a amebíase invasiva
Fecha
2015-03-05Autor
Mercia Aurelia Goncalves Leite
Institución
Resumen
The effect of ethnicity in the prevalence of diseases as well as in its clinical form, is widely studied, however, no research reports about the ancestry of individuals and their susceptibility to parasitic infections. In this study the possible relationship between the individual's ancestry and occurrence of invasive amebiasis. Samples of oral mucosal cells were collected for determination of genetic ancestry, blood serology, stool to coproscopia and parasitological examination of individuals residing in Belém-PA. The sites were the Evandro Chagas Institute and University Hospital João de Barros Barreto. A health-food questionnaire was applied directly prior to collection. In 40% of the samples evaluated in the EPF, found some kind of parasite. The complex E. histolytica / E. dispar showed 9.7% positivity. Serology for amebiasis showed high positive (44.03%), confirming the endemicity of the disease in the region. The substructures of the genomic region showed a higher proportion of Europeans (78.7%), followed by Native Americans (12.4%) and finally Africans (8.9%). The association of ancestry serology for amebiasis revealed that both African ancestry as the Amerindian impacted significantly to the presence of positive serology. On the other hand, European ancestry impacted significantly on positive serology, and for every 10% increase in European ancestry, decreased by 6.1 the chance of positive serology occur. Despite the health questionnaire answers reveal food low socioeconomic status of the population under study found no association between any of the items evaluated with the highest prevalence of amebiasis or intestinal parasites. In conclusion, our study showed that the greater the contribution of European ancestry in an individual, the less chance of developing invasive amebiasis. Considering the great inter-ethnic mix in Brazil, other regions should be studied to confirm these results continuing to study the mechanisms involved in protection and disposition of European, African and Amerindian invasive amebiasis.