dc.contributor | Juliana Alvares Teodoro | |
dc.contributor | http://lattes.cnpq.br/8338204270737352 | |
dc.contributor | Alessandra Maciel de Almeida | |
dc.contributor | Paulo Henrique Costa Diniz | |
dc.contributor | Daniel Resende Faleiros | |
dc.creator | Rafael de Souza Matos | |
dc.date.accessioned | 2022-02-02T13:52:05Z | |
dc.date.accessioned | 2022-10-03T22:20:44Z | |
dc.date.available | 2022-02-02T13:52:05Z | |
dc.date.available | 2022-10-03T22:20:44Z | |
dc.date.created | 2022-02-02T13:52:05Z | |
dc.date.issued | 2021-09-28 | |
dc.identifier | http://hdl.handle.net/1843/39256 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3799868 | |
dc.description.abstract | A neoplasm that mainly affects the elderly, aged between 64 and 70 years, the chronic
lymphocytic leukemia (CLL) is characterized by the accumulation of B lymphocytes in
the blood, secondary lymphoid tissues and marrow. Its cause is unknown, it provides
an increased risk for anemia, hemorrhage and infections, and the clinical course varies
among patients. Combined with other first-line chemotherapy, the anti-CD20
monoclonal antibody rituximab has good results in therapy, according to some studies.
Rituximab is a high-cost drug and, currently, the amount transferred by the Unified
Health System (SUS) for the first-line treatment of CLL is lower than its financial value.
In this scenario, it is proposed to conduct a health technology assessment (HTA), with
analysis of effectiveness, safety and economic assessment through the budget impact
analysis (BIA). For the evaluation, we performed a systematic review with network
meta-analysis of anti-CD20 monoclonal antibodies for the treatment of CLL and an
analysis of the budgetary impact of rituximab in the treatment of the disease. In the
classification of the meta-analysis, the associations containing rituximab demonstrated
results that were superior to the standard therapy applied in the SUS, especially
regarding the outcomes of overall survival and progression-free survival, except in
terms of adverse reactions. The BIA model developed showed an increase in costs
with the incorporation of the drug at the end of five years, however, among the
proposed scenarios, the one that estimated greater market diffusion for rituximab had
a lower total cost. The BIA performed provided better future financial visualization
related to the incorporation of rituximab in order to contribute, together with a cost-
effectiveness analysis, with information necessary for the budget planning of the SUS. | |
dc.publisher | Universidade Federal de Minas Gerais | |
dc.publisher | Brasil | |
dc.publisher | FARMACIA - FACULDADE DE FARMACIA | |
dc.publisher | Programa de Pós-Graduação em Medicamentos e Assistencia Farmaceutica | |
dc.publisher | UFMG | |
dc.rights | Acesso Aberto | |
dc.subject | Linfócitos B | |
dc.subject | Leucemia linfocítica crônica | |
dc.subject | Rituximabe | |
dc.subject | Sistema Único de Saúde (SUS) | |
dc.subject | Avaliação de tecnologias em saúde | |
dc.subject | Análise impacto orçamentário | |
dc.title | Avaliação da segurança e eficácia dos anticorpos monoclonais anti-CD20 no tratamento da leucemia linfocítica crônica e impacto orçamentário da incorporação do rituximabe no SUS | |
dc.type | Dissertação | |