| dc.creator | Quintá, Héctor R. | |
| dc.creator | Barrantes, Francisco José | |
| dc.date | 2022-08-19T11:42:38Z | |
| dc.date | 2022-08-19T11:42:38Z | |
| dc.date | 2019 | |
| dc.identifier | Quintá, H.R., Barrantes, F.J. Damage and repair of the axolemmal membrane: From neural development to axonal trauma and restoration [en línea]. En: Andrade. L.O. (ed.). Plasma Membrane Repair (Current Topics in Membranes, 84). Elsevier, 2019 doi:10.1016/bs.ctm.2019.07.007 Disponible en: | |
| dc.identifier | 978-0-12-817760-0 | |
| dc.identifier | 1063-5823 | |
| dc.identifier | https://repositorio.uca.edu.ar/handle/123456789/14690 | |
| dc.identifier | 10.1016/bs.ctm.2019.07.007 | |
| dc.identifier | 31610861 | |
| dc.description | Abstract: Integrity of the plasma membrane is essential for the maintenance of physiological
conditions, metabolic activity and the shape of eukaryotic cells. In neurons, the plasma
membrane surrounding the axon—the axolemma—fulfills all these functions plus
those inherent to the specific function of the neuron: maintaining the membrane
potential by the regulated and concerted operation of ion-selective channels. Membrane
expansion and neurite growth are directly linked through intricate cellular signaling
mechanisms during the early stages of embryonic development. During axonal
development there is an increase in the surface area of the axolemma which provokes
an increase in membrane tension. Membrane insertion involved in axonal growth
reduces the membrane tension, and this in turn allows distal membrane expansion
and axonal extension. Under certain pathological conditions, such as spinal cord and
traumatic brain injuries, the axolemmal damage results in different degrees of neuronal degeneration due to unregulated ionic influx, followed by oxidative damage, finally
triggering neuronal apoptosis. Neurons possess counteractive mechanisms to arrest
these degenerative processes which involve sealing the axolemma as a first step toward
membrane repair, followed by attempts at axonal extension. In this review we address
the main molecular actors and mechanisms involved in axonal growth during embryonic
development and the recapitulation of these mechanisms during the posttraumatic
regeneration process. We also discuss the efficacy of some classical and novel
therapeutic approaches to axolemmal sealing and repair in different pathologies. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Elservier | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.source | Andrade. L.O. (ed.). Plasma Membrane Repair (Current Topics in Membranes, 84). Elsevier, 2019 | |
| dc.subject | AXONES | |
| dc.subject | MEMBRANAS CELULARES | |
| dc.title | Damage and repair of the axolemmal membrane: from neural development to axonal trauma and restoration | |
| dc.type | Parte de libro | |
