| dc.creator | Sarasola, María de la Paz | |
| dc.creator | Táquez Delgado, Mónica Alejandra | |
| dc.creator | Nicoud, Melisa Beatriz | |
| dc.creator | Medina, Vanina Araceli | |
| dc.date | 2022-07-26T13:40:40Z | |
| dc.date | 2022-07-26T13:40:40Z | |
| dc.date | 2021 | |
| dc.identifier | Sarasola, M. d. l. P. et al. Histamine in cancer immunology and immunotherapy: current status and new perspectives [en línea]. Pharmacology research & perspectives. 2021, 9 (5). doi: https://doi.org/10.1002/prp2.778. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14563 | |
| dc.identifier | 2052-1707 | |
| dc.identifier | https://repositorio.uca.edu.ar/handle/123456789/14563 | |
| dc.identifier | 10.1002/prp2.778 | |
| dc.description | Abstract:
Cancer is the second leading cause of death globally and its incidence and mortality
are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor
cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront of cancer treatments, resulting in impressive and durable responses but only in
a fraction of patients. Thus, understanding the characteristics and profiles of immune
cells in the tumor microenvironment (TME) is a necessary step to move forward in the
design of new immunomodulatory strategies that can boost the immune system to
fight cancer. Histamine produces a complex and fine-tuned regulation of the phenotype and functions of the different immune cells, participating in multiple regulatory
responses of the innate and adaptive immunity. Considering the important actions
of histamine-producing immune cells in the TME, in this review we first address the
most important immunomodulatory roles of histamine and histamine receptors in the
context of cancer development and progression. In addition, this review highlights
the current progress and foundational developments in the field of cancer immunotherapy in combination with histamine and pharmacological compounds targeting
histamine receptors. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | John Wiley & Sons | |
| dc.rights | Acceso abierto | |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.source | Pharmacology research & perspectives Vol.9, No.5, 2021 | |
| dc.subject | CANCER DE MAMA | |
| dc.subject | INMUNIDAD ADAPTATIVA | |
| dc.subject | INMUNIDAD ANTITUMORAL | |
| dc.subject | RECEPTORES DE HISTAMINA | |
| dc.subject | INMUNOTERAPIA | |
| dc.subject | INMUNIDAD INNATA | |
| dc.subject | LEUCEMIA | |
| dc.title | Histamine in cancer immunology and immunotherapy: current status and new perspectives | |
| dc.type | Artículo | |
