| dc.creator | Paulazo, Maria Alejandra | |
| dc.creator | Klecha, Alicia Juana | |
| dc.creator | Sterle, Helena Andrea | |
| dc.creator | Valli, Eduardo | |
| dc.creator | Torti, Horacio | |
| dc.creator | Cayrol, María Florencia | |
| dc.creator | Barreiro Arcos, María Laura | |
| dc.creator | Cremaschi, Graciela A. | |
| dc.date | 2022-06-23T14:55:12Z | |
| dc.date | 2022-06-23T14:55:12Z | |
| dc.date | 2019 | |
| dc.identifier | Paulazo, M.A., et al. Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity [en línea]. Endocrine. 2019, 66 doi:10.1007/s12020-019-01936-7 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14235 | |
| dc.identifier | 1559-0100 | |
| dc.identifier | https://repositorio.uca.edu.ar/handle/123456789/14235 | |
| dc.identifier | 10.1007/s12020-019-01936-7 | |
| dc.identifier | 31056723 | |
| dc.description | Abstract: Purpose Hypothyroidism has been shown to induce immunosuppression and both the thyroid status and immunity are
affected by zinc deficiency. However, the impact of hypothyroidism on zinc metabolism and its possible relationship with
the immune status has not yet been deeply explored. Here, our aim was to study whether hypothyroidism may alter zinc
metabolism and thus lead to the impairment of T lymphocyte activity.
Methods Variations in the distribution of zinc in the body were evaluated in PTU-treated hypothyroid mice. The effects of
hypothyroidism and zinc deficiency were studied on T lymphocyte proliferation after stimulation both in vitro and in vivo.
For in vitro assays, thyroid hormone-free or zinc chelator (TPEN or DTPA)-supplemented media were used. For in vivo
assays, lymphocyte activity was evaluated in cells from hypothyroid, T3-treated, and zinc-supplemented mice.
Results Hypothyroid mice showed lower levels of zinc in femur and lymph nodes than controls. T3 and zinc supplementation
reversed these effects. In vitro, both thyroid hormone and zinc deficiency led to a decreased response to mitogen
stimulation. However, only zinc deficiency was able to induce lymphocyte apoptosis. Mitogen-stimulated T cells from
hypothyroid mice showed impaired proliferation, accompanied by decreased activation of PKC and lower levels of p-ERK,
effects that were reversed by T3 replacement or zinc supplementation.
Conclusions Our results show an important role of zinc deficiency in hypothyroid-mediated T-cell suppression and suggest
the importance of evaluating zinc levels and restoring them when necessary to maintain an efficient immune response in
hypothyroid patients. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Springer | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.source | Endocrine. 2019, 66 | |
| dc.subject | GLANDULA TIROIDES | |
| dc.subject | HIPOTIROIDISMO | |
| dc.subject | LINFOCITOS T | |
| dc.subject | ZINC | |
| dc.title | Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity | |
| dc.type | Artículo | |
