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Excessive buccal saliva in patients with Parkinson’s Disease of the French COPARK cohort
Fecha
2020Registro en:
0300-9564 (impreso)
1435-1463 (online)
10.1007/s00702-020-02249-0
Autor
Rascol, Olivier
Negre-Pages, Laurence
Damier, Philippe
Delval, Arnaud
Derkinderen, Pascal
Destée, Alain
Fabbri, Margherita
Meissner, Wassilios G.
Rachdi, Amine
Tison, François
Pérez Lloret, Santiago
Institución
Resumen
Abstract: Introduction: We describe excessive buccal saliva (EBS) prevalence in patients with Parkinson’s Disease (PD) and controls of the COPARK study, its changes between “ON” and OFF” conditions and over time, its impact on Health-related Quality of life (HRQoL), and factors associated with this condition.
Methods: We studied 671 ambulatory PD patients and 177 age/sex-matched controls. We defined “sialorrhea” as UPDRS item #6 (salivation)=1 or 2; and “drooling” as item #6=3 or 4. SCOPA-Aut drooling score (item #2) was also available in a subset (45%) of the cohort. HRQoL was assessed by the PDQ-39 and SF-36 scales. Twenty-four months follow-up data was available in 401/671 patients.
Results: EBS as assessed by UPDRS was present in 38% of PD patients in the “ON” condition (“Sialorrhea”: 35%; “drooling”: 3%). There were also more PD patients reporting “drooling” than controls according to the SCOPA-Aut (49% vs 19%, p<0.01). UPDRS salivation score was worse in the “OFF” vs “ON” condition in PD patients with motor fluctuations (0.90±0.94 vs 0.54±0.79, p<0.01). UPDRS salivation score worsened after 24 months of follow up (0.47±0.70 vs 0.64±0.81, p<0.01). Worse PDQ-39 scores were observed in PD patients with EBS in bivariate but not in multivariate analyses. EBS was directly related to PD duration and severity, male gender, dysphagia, hypomimia, and autonomic dysfunction (logistic regression).
Conclusions: EBS was more frequent in PD patients than controls, worsened in the “OFF” condition and after 24 months of follow-up, moderately affected HRQoL and was correlated with indices of bradykinesia, dysphagia, and autonomic dysfunction.