Trastornos del sueño en pacientes con esclerosis multiple en el Hospital Militar Central del 2011 al 2015

dc.creatorAcosta Bolivar, Alberto Jose
dc.creatorGuzmán Molano, Luisa Fernanda
dc.creatorCentanaro Meza, Gabriel Adolfo
dc.date.accessioned2017-05-26T00:19:51Z
dc.date.accessioned2019-12-30T19:04:47Z
dc.date.accessioned2022-09-28T21:06:31Z
dc.date.available2017-05-26T00:19:51Z
dc.date.available2019-12-30T19:04:47Z
dc.date.available2022-09-28T21:06:31Z
dc.date.created2017-05-26T00:19:51Z
dc.date.created2019-12-30T19:04:47Z
dc.identifierhttp://hdl.handle.net/10654/15671
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3740804
dc.description.abstractIntroducción: La Esclerosis Múltiple (MS), es una enfermedad desmielinizante mediada inmunológicamente, se estima que más de dos millones de personas en todo el mundo sufren esta enfermedad, la cual es una de las causas más comunes de discapacidad neurológica en adultos jóvenes, aunque a menudo no reconocida clínicamente, los trastornos del sueño (insomnio, trastornos respiratorios del sueño y síndrome de piernas inquietas) se presentan en los pacientes con MS con más frecuencia que en la población general. Materiales y métodos: Estudio de serie de casos en el que se evaluó la presentación de los trastornos del sueño en paciente con Esclerosis Múltiple atendidos entre el 2011 y 2015, en el Hospital Militar Central de Bogotá, utilizando como Instrumentos de medición, las escalas de Epworth Sleepiness Scale , Insomnia Severity Index , STOP-BANG Questionnaire, e International Restless Legs Syndrome Scale, Los datos obtenidos de los instrumentos de medición se procesaron con el paquete estadístico SPSS. Resultados: El presente estudio reportó una frecuencia elevada de trastornos del sueño en pacientes con Esclerosis Múltiple, 12 de los 15 pacientes paciente presentaron algún trastorno del sueño, siendo más frecuente en mujeres, el trastorno del sueño más frecuente fue el insomnio, 6 pacientes con insomnio subclínico y 3 pacientes insomnio moderado, seguido por el síndrome de piernas inquietas 8 de los 15 pacientes y 6 pacientes con riesgo de OSA (5 riesgo intermedio de OSA y 1 riesgo alto), además 4 pacientes presentaron somnolencia diurna diaria. Conclusión: El presente estudio reporto una frecuencia elevada de trastornos de sueño en los pacientes con Esclerosis Múltiple, especialmente en insomnio moderado y síndrome de piernas inquietas (moderado a muy grave), en los pacientes de género femenino, lo cual resalta la importancia de indagar por estos trastornos en la práctica clínica diaria. Una frecuencia importante de nuestros pacientes presento riesgo para OSA y somnolencia diurna diaria, de los cuales se confirmaron 2 pacientes con OSA mediante estudio polisomnografico, de aquí la importancia de la realización de un protocolo diagnóstico de los trastornos del sueño en paciente con MS.
dc.publisherUniversidad Militar Nueva Granada
dc.publisherFacultad de Medicina
dc.publisherNeurología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceCompston A, Coles A. Multiplesclerosis. Lancet 2008 Oct 25; 372(9648): 1502-17.
dc.sourceSteinman L. Multiple sclerosis: a two-stage disease.Nat Immunol 2001Sep;2(9):762-4.
dc.sourceKingwell E, Marriott JJ, Jette N, Pringsheim T, Makhani N, Morrow SA, et al Incidence and prevalence of multiple sclerosis in Europe: a systematic review. BMC Neurol 2013 Sep 26;13(1):128.
dc.sourceFrohman EM, Racke MK, Raine CS. Multiple sclerosis the plaque and its pathogenesis. N Engl J Med 2006 Mar 2;354(9):942-55.
dc.sourceTrapp BD, Peterson J, Ransohoff RM, Rudick R, S Mork, Bo L. axonaltranseción en las lesiones de la esclerosis múltiple. N Engl J Med 1998 29 de enero; 338 (5): 278-85.
dc.sourceAllegretta M, Nicklas JA, Sriram S, Albertini RJ. T cells responsive to myelinbasic protein in patients with multiple sclerosis. Science 1990 Feb9;247(4943):718-21.
dc.sourceZhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J ExpMed 1994 Mar 1;179(3):973-84.
dc.sourceWucherpfennig KW, Strominger JL. El mimetismo molecular en las células T mediada autoinmunidad: péptidos virales activar los clones de células T humanas específicas para proteína básica de mielina. Cell 1995; 80 (7534214): 695-705.
dc.sourceDimitriosKarussis,The diagnosis of multiple sclerosis and the various related demyelinating syndromes: A critical review. Journal of Autoimmunity 48-49 (2014) 134-142.
dc.sourceTachibana N, Howard R, Hirsch N, Miller D, Moseley I, Fish D. Sleep problems in multiple sclerosis. EurNeurol 1994;34:320–23.
dc.sourceBamer A, Johnson K, Amtmann D, Kraft G. Prevalence of sleep problems in individuals with multiple sclerosis. MultScler 2008;14:1127-30.
dc.sourceLunde HMB, Bjorvatn B, Myhr K-M, Bø L. Clinical management of sleep disorders in multiple sclerosis: a literature review. ActaNeurolScand 2013: 127 (Suppl. 196): 24–30.
dc.sourceFleming WE, Pollak CP Sleep disorders in multiple sclerosis. Semin Neurol 2005;25:64–8.
dc.sourceKaminska M, Kimoff R, Benedetti A, et al. Obstructive sleep apnea isassociated with fatigue in multiple sclerosis. MultScler 2012;18:1159-69.
dc.sourceLUIGI FERINI-STRAMBI Sleep disorders in multiple sclerosis Handbook of Clinical Neurology, Vol. 99 (3rd series) Sleep Disorders, Part 2.
dc.sourceKapsimalis F, Basta M, Varouchakis G, Gourgoulianis K, Vgontzas A,Kryger M. Cytokines and pathological sleep.Sleep Med 2008;9(6):603-14
dc.sourcePayne LC, Krueger JM. Interactions of cytokines with the hypothalamus–pituitary axis. J Immunother 1992;12(3):171–3.
dc.sourceKrueger JM, Oba´ l FJ, Fang J, Kubota T, Taishi P. The role of cytokines in physiological sleep regulation. Ann N Y AcadSci 2001;933:211–21.
dc.sourceCavadini G, Petrzilka S, Kohler P, Jud C, Tobler I, Birchler T, et al. TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proc Natl AcadSci U S A 2007;104(31):12843–8.
dc.sourcePayne LC, Oba´ l F, Krueger JM. Hypothalamic releasing hormones mediating the effects of interleukin-1 on sleep. J Cell Biochem 1993;53(4):309–13.
dc.sourceHeesen C, Koehler G, Gross R, Tessmer W, Schulz KH, Gold SM. Alteredcytokine responses to cognitive stress in multiple sclerosis patients withfatigue. MultScler 2005; 11(1):51–7.
dc.sourceHauser SL, Doolittle TH, Lincoln R, Brown RH, Dinarello CA. Cytokineaccumulations in CSF of multiple sclerosis patients: frequent detection ofinterleukin-1 and tumor necrosis factor but not interleukin-6. Neurology1990; 40(11):1735–9.
dc.sourceKripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR. Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry 2002; 59(2):131–6.
dc.sourcePatel SR, Redline S. Two epidemics: are we getting fatter as we sleep less? Sleep 2004;27(4):602–3.
dc.sourceAyas NT, White DP, Al-Delaimy WK, Manson JE, Stampfer MJ, Speizer FE, et al. A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care 2003;26(2):380–4.
dc.sourceAyas NT, White DP, Manson JE, Stampfer MJ, Speizer FE, Malhotra A, et al. A prospective study of sleep duration and coronary heart disease in women. Arch Intern Med 2003;163(2):205–9.
dc.sourceStanton BR, Barnes F, Silber E. Sleep and fatigue in multiple sclerosis. MultScler 2006;12(4):481–6.
dc.sourceMerlino G, Fratticci L, Lenchig C, Valente M, Cargnelutti D, Picello M, et al. Prevalence of poor sleep among patients with multiple sclerosis: an independent predictor of mental and physical status. Sleep Med 2009; 10(1):26–34.
dc.sourceKaynak H, Altintas， A, Kaynak D, Uyanik O, Saip S, Ag˘aog˘lu J, et al. Fatigue and sleep disturbance in multiple sclerosis. Eur J Neuro 2006;13(12):1333– 9.
dc.sourceAttarian HP, Brown KM, Duntley SP, Carter JD, Cross AH. The relationship of sleep disturbances and fatigue in multiple sclerosis. Arch Neurol 2004; 61(4):525–8.
dc.sourceAASM. The international classification of sleep disorders, diagnostic and coding manual. 2nd edition. Westchester (IL): American Academy of Sleep Medicine; 2005.
dc.sourceSchutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med 2008; 4:487–504.
dc.sourceMORIN CM, BENCA R. Chronic insomnia. Lancet 2012; 379:1488.
dc.sourceCRAYTON H, HEYMAN RA, ROSSMAN HS. A multimodal approach to managing the symptoms of multiple sclerosis. Neurology 2004;63(11Suppl 5):S12–S18.
dc.sourceAllen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisir J. Restless legs syndrome diagnosis and epidemiology workshop at the National Institute of Health; International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 2003; 4:101–19.
dc.sourceng WA, Allen RP, Chaudhuri KR, Hornyak M, Lee HB, Winkelman J, et al. Clinical significance of RLS. MovDisord 2007; 22(Suppl. 18): S395–400.
dc.sourceSchormair B, Kemlink D, Roeske D, Eckstein G, Xiong L, Lichtner P, et al. PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. Nat Genet 2008; 40(8):946–8.
dc.sourceAllen RP, Earley CJ. The role of iron in restless legs syndrome. MovDisord 2007; 22(Suppl. 18):S440–8.
dc.sourceBrass SD, Chen NK, Mulkern RV, Bakshi R. Magnetic resonance imaging of iron deposition in neurological disorders. Top MagnReson Imaging 2006; 17(1):31–40.
dc.sourceOndo WG. Restless legs syndrome. NeurolClin 2009; 27:779–99.
dc.sourceHögl B, Kiechl S, Willeit J, Saletu M, Frauscher B, Seppi K, et al. Restless legs syndrome: a community-based study of prevalence, severity, and risk factors. Neurology 2005; 64:1920–4.
dc.sourceAuger C, Montplaisir J, Duquette P. Increased frequency of restless legs syndrome in a French–Canadian population with multiple sclerosis. Neurology 2005; 65: 1652–3.
dc.sourceDeriu M, Cossu G, Molari A, Murgia D, Mereu A, Ferrigno P, et al. Restless legs syndrome in multiple sclerosis: a case–control study. MovDisord 2009; 24: 697–701.
dc.sourceItalian REMS Study Group, Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Iudice A, et al. Multicenter case–control study on restless legs syndrome in multiple sclerosis: the REMS study. Sleep 2008; 31:944–52.
dc.sourceYoung T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middleaged adults. N Engl J Med 1993;328:1230-5.
dc.sourceBraley, T., Segal, B. and Chervin, R. (2014b) Obstructive sleep apnea and fatigue in patients with multiple sclerosis. J Clin Sleep Med 10: 155–162.
dc.sourceBraley, T., Segal, B. and Chervin, R. (2012b) Sleep disordered breathing in multiple sclerosis. Neurology 79: 929–936.
dc.sourceBrass, S., Li, C. and Auerbach, S. (2014) Theunderdiagnosis of sleep disorders in patients with multiple sclerosis. J Clin Sleep Med 10: 1025–1031.
dc.sourceVeauthier, C., Gaede, G., Radbruch, H., Gottschalk, S., Wernecke, K. and Paul, F. (2013) Treatment of sleep disorders may improve fatigue in multiple sclerosis. ClinNeurolNeurosurg115: 1826–1830.
dc.sourceVeauthier, C. and Paul, F. (2012) Fatigue in multiple sclerosis: which patient should be referred to a sleep specialist MultScler18: 248–249.
dc.sourceBraley, T., Kratz, A., Kaplish, N. and Chervin, R. (2014a) Cognitive dysfunction in multiple sclerosis is associated with obstructive sleep apnea. Sleep. 2016 Aug 1; 39(8):1525-33.
dc.sourceTrojan, D., Kaminska, M., Bar-Or, A., Benedetti, A., Lapierre, Y., Da Costa, D. et al. (2012) Polysomnographic measures of disturbed sleep are associated with reduced quality of life in multiple sclerosis. J NeurolSci316: 158–163.
dc.sourceHublin C, Kaprio J, Partinen M, Koskenvuo M, Heikkila K, Koskimies S, et al. The prevalence of narcolepsy: an epidemiological study of the Finnish Twin Cohort. Ann Neurol 1994; 35(6):709–16.
dc.sourceIseki K, Mezaki T, Oka Y, Terada K, Tomimoto H, Miki Y, et al. Hypersomnia in MS. Neurology 2002;59(12):2006–7.
dc.sourceBerg O, Hanley J. Narcolepsy in two cases of multiple sclerosis. ActaNeurolScand 1963; 39:252–6.
dc.sourceNishino S, Kanbayashi T. Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin/orexin system. Sleep Med Rev 2005; 9(4):269–310.
dc.sourceSchrader H, Gotlibsen OB, Skomedal GN. Multiple sclerosis and narcolepsy/ cataplexy in a monozygotic twin. Neurology 1980; 30(1):105-8.
dc.sourceVetrugno R, Stecchi S, Plazzi G, Lodi R, D’Angelo R, Alessandria M, et al. Narcolepsy-like syndrome in multiple sclerosis. Sleep Med 2009; 10:389–91.
dc.sourceYounger DS, Pedley TA, Thorpy MJ. Multiple sclerosis and narcolepsy: possible similar genetic susceptibility. Neurology 1991; 41(3):447–8.
dc.sourceFrenette E. REM sleep behavior disorder. Med Clin North Am 2010; 94:593
dc.sourceTaphoorn MJ, van Someren E, Snoek FJ, Strijers RL, Swaab DF, Visscher F, et al. Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis. J Neurol 1993; 240 (7):446–8
dc.sourceMurray Jhon , A new method for measuring daytime sleepiness: the Epworth sleepiness scale,Sleep.1991 Dec; 14(6):540-5
dc.sourceHeydy Luz Chica-Urzola, Franklin Escobar-Córdoba y Javier Eslava-Schmalbach, Validación de la Escala de Somnolencia de Epworth, ValidatingtheEpworthsleepinessscale, Rev. Salud pública. 9 (4):558-567, 2007
dc.sourceBASTIEN CH, Vallieres A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001; 2:297-307.
dc.sourceSierra JC, Guillen-Serrano V, Santos-Iglesias P. Insomnia severity index: Some indicators about its reliability and validity on an older adults sample. Rev Neurol.2008; 47:566–70.24
dc.sourceFernandez-Mendoza J, Rodriguez-Muñoz A, Vela-Bueno A,Olavarrieta-Bernardino S, Calhoun SL, Bixler EO. The Spanish version of the Insomnia Severity Index: A confirmatory factor analysis. SleepMed. 2012; 13:207–10.25.
dc.sourceGuía de Práctica Clínica para el Manejo de Pacientes con Insomnio en Atención Primaria , MINISTERIO DE SANIDAD Y POLÍTICA SOCIAL, 2009. Guía de Práctica Clínica: Nº 2007/5-1. Madrid España.
dc.sourceRicardo Díaz, Mario Iván Ruano, Prevalencia y persistencia del insomnio crónico Estudio SUECA II ,ActaMedColomb 2011; 36: 119-124
dc.sourceChung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, Khajehdehi A, Shapiro CM. STOP questionnaire: a tool to screen patients for obstructive sleep apnea. Anesthesiology. 2008 May; 108(5): 812-21.
dc.sourceChung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, Khajehdehi A, Shapiro CM. Validation of the Berlin questionnaire and American Society of Anesthesiologists checklist as screening tools for obstructive sleep apnea in surgical patients. Anesthesiology. 2008 May; 108(5): 822-30.
dc.sourceAna KD, Silva GE, Goldberg R. Predictive abilities of the STOP-Bang and Epworth Sleepiness Scale in identifying sleep clinic patients at high risk for obstructive sleep apnea. Res NursHealth. 2013 Feb; 36(1): 84-94
dc.sourceRuiz AJ, Martín Alonso Rondón Sepúlveda , Patricia Hidalgo Martínez , Martín Cañón Muñoz , Liliana Otero Mendoza , Olga Patricia PanquevaCentanaro , Luis Felipe Uriza Carrasco, Juan Camilo Ospina García, Prevalence of sleepcomplaints in Colombia at different altitudes, SleepScience 9 (2016) 100–105.
dc.sourceTrenkwalder C, Kohnen R, Allen RP, Benes H, Ferini-Strambi L, García-Borreguero D, et al. Clinical trials in restless legs syndrome – Recommendations of the European RLS Study Group (EURL SSG). MovDisord. 2007; 22 Suppl.18: S495-S504.
dc.sourceArthur S. Walters Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome The International Restless Legs Syndrome Study Group Sleep Medicine 4 (2003) 121–132.
dc.subjectEsclerosis Múltiple
dc.subjectTrastornos del sueño
dc.subjectInsomnio
dc.subjectSíndrome de piernas inquietas
dc.subjectTrastornos respiratorios del sueño
dc.subjectSomnolencia diurna diaria.
dc.titleTrastornos del sueño en pacientes con esclerosis multiple en el Hospital Militar Central del 2011 al 2015
dc.typeinfo:eu-repo/semantics/bachelorThesis


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