Features of dengue and chikungunya infections of colombian children under 24 months of age admitted to the emergency department
Fecha
2018Registro en:
Paternina-Caicedo A., De la Hoz-Restrepo F., Díaz-Quijano F., Caicedo-Torres W., Badillo-Viloria M.A., Bula-Anichiarico D., Alvis-Guzmán N., Mattar S., Constenla D. y Pinzón-Redondo H. (2018) Features of dengue and chikungunya infections of colombian children under 24 months of age admitted to the emergency department. Journal of Tropical Pediatrics; Vol. 64, Núm. 1; pp. 31-37
1426338
10.1093/tropej/fmx024
Universidad Tecnológica de Bolívar
Repositorio UTB
35769665400
14022599400
9532887500
55782426500
57201395899
56705381100
57210741239
7005860176
14057575400
56375235000
Autor
Paternina-Caicedo A.
De la Hoz-Restrepo F.
Díaz-Quijano F.
Caicedo-Torres W.
Badillo-Viloria M.A.
Bula-Anichiarico D.
Alvis-Guzmán N.
Mattar S.
Constenla D.
Pinzón-Redondo H.
Resumen
We aimed to assess clinical and laboratory differences between dengue and chikungunya in children <24 months of age in a comparative study. We collected retrospective clinical and laboratory data confirmed by NS1/IgM for dengue for 19 months (1 January 2013 to 17 August 2014). Prospective data for chikungunya confirmed by real-time polymerase chain reaction were collected for 4 months (22 September 2014-14 December 2014). Sensitivity and specificity [with 95% confidence interval (CI)] were reported for each disease diagnosis. A platelet count <150 000 cells/ml at emergency admission best characterized dengue, with a sensitivity of 67% (95% CI, 53-79) and specificity of 95% (95% CI, 82-99). The algorithm developed with classification and regression tree analysis showed a sensitivity of 93% (95% CI, 68-100) and specificity of 38% (95% CI, 9-76) to diagnose dengue. Our study provides potential differential characteristics between chikungunya and dengue in young children, especially low platelet counts. © The Author [2017].