dc.creatorGalvis, Fabian
dc.creatorMoreno Rozo, laura Yolima
dc.date.accessioned2021-12-09T20:41:04Z
dc.date.accessioned2022-09-28T18:31:47Z
dc.date.available2021-12-09T20:41:04Z
dc.date.available2022-09-28T18:31:47Z
dc.date.created2021-12-09T20:41:04Z
dc.date.issued2019-06
dc.identifierhttp://repositorio.ufps.edu.co/handle/ufps/1781
dc.identifierhttp://dx.doi.org/10.4067/S0716-10182019000300304
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3704328
dc.description.abstractBackground: The expression of CTX-M β-lactamases belonging to groups 1 and 9 in Klebsiella pneumoniae produces high levels of resistance to ceftazidime, and they have a wide distribution worldwide. Aim: To identify and characterize the blaCTX-M-Group1 and blaCTX-M-Group9 genes in K. pneumoniae isolates resistant to ceftazidime in a hospital in San José de Cúcuta, Colombia. Material and Methods: Primers were designed for the identification of K. pneumoniae and blaCTX-M genes by PCR. Subsequently, the genetic relationship of these isolates was analyzed by REP-PCR. Results: A 38% of the 24 isolates identified by PCR as K. pneumoniae showed blaCTX-M-3. blaCTX-M-15 y blaCTX-M-32 genes (Group CTX-M-1) and 42% blaCTX-M14. blaCTX-M-24 y blaCTX-M-27 genes (Group CTX-M-9). The phylogenetic analysis grouped the K. pneumoniae isolates into 4 clusters, showing correlation in clusters I, II and IV, when comparing the genetic profiles with the type of sample and group of genes. Discussion: We found a similar frequency of blaCTX-M-Group 1 and blaCTX-M-Group 9 genes in isolates of K. pneumoniae resistant to ceftazidime. The correlation between the REP-PCR with the CTX-M groups and the type of sample revealed the presence of three clonal pattern
dc.languageeng
dc.publisherRevista Chilena de Infectologia
dc.publisherSantiago de Chile , Chile
dc.relationRevista chilena de infectología
dc.relationVol.36 No.3.(2019)
dc.relation311
dc.relation3 (2019)
dc.relation304
dc.relation36
dc.relationGalvis, F., & Moreno, L. (2019). Caracterización molecular y detección de genes blaCTX-M grupos 1 y 9 en Klebsiella pneumoniae resistentes a ceftazidima, en un hospital de San José de Cúcuta, Colombia. Revista chilena de infectología, 36(3), 304-311.
dc.relationMolecular characterization and detection of genes blaCTX-M groups 1 and 9 in Klebsiella pneumoniae resistant to ceftazidime, in a hospital in San José de Cúcuta, Colombia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.sourcehttps://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182019000300304&lng=en&nrm=iso&tlng=en
dc.titleCaracterización molecular y detección de genes blaCTX-M grupos 1 y 9 en Klebsiella pneumoniae resistentes a ceftazidima, en un hospital de San José de Cúcuta, Colombia
dc.typeArtículos de revistas


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