Aplicabilidad biotecnológica de aceites esenciales de Lippia alba

dc.contributorGutiérrez Castañeda, Clara
dc.contributorOrtega Cuadros, Mailen
dc.creatorAcosta De Guevara, Ema
dc.creatorMolina Castillo, Ailen
dc.date.accessioned2020-01-31T20:08:53Z
dc.date.available2020-01-31T20:08:53Z
dc.date.created2020-01-31T20:08:53Z
dc.identifierhttps://hdl.handle.net/10901/17821
dc.description.abstractSe desarrolló un estudio descriptivo con el objetivo de determinar las líneas de aplicabilidad biotecnológica del aceite esencial de Lippia alba mediante el análisis integrado de vigilancia tecnológica. La metodología incluyó una revisión sistemática exploratoria de artículos científicos en las bases de datos EBSCO, Embase, PubMed, Scopus, SciELO y Lilacs; y la búsqueda de patentes en bases de datos comerciales y gratuitas. La información obtenida se analizó utilizando los gestores bibliográficos Mendeley®, Zotero®, los programas Microsoft Excel® 2016, GraphPrad® versión 7, Paint3D®, y el paquete estadístico IBM SPSS® versión 23.0. Los resultados indican que los aceites esenciales son temas de interés en la comunidad científica desde la década de 1990, y que Brasil (60,5%), Colombia (25,2%) e India (6,2%) son los países que más le apuestan a este tipo de investigaciones para solventar problemáticas en los sectores biomédico y agroindustrial. Los investigadores han evaluado una amplia variedad de organismos y microorganismos sobre los cuales el aceite esencial de Lippia alba tiene efectos biológicos. También se identificó mediante el seguimiento de las patentes que los principales actores interesados en la industrialización de esta especie aromática se encuentran en Brasil, los EE. UU, Japón, Francia, Canadá e India, y están enfocados en el desarrollo de tecnologías para responder a las demandas relacionadas con las categorías A (necesidades corrientes de la vida) y C (química; metalurgia). Lippia alba es una planta medicinal promisoria en Iberoamérica, incluida en el Vademécum colombiano de plantas medicinales y con venta libre aprobada como antiséptico de uso externo en seres humanos. En Colombia el mercado de las plantas medicinales está poco desarrollado y su mayor movimiento se da mediante mercados informales, esto dificulta la inclusión de especies nativas y sus derivados a los mercados internacionales. Sin embargo, la generación de alianzas estratégicas con actores clave en los ámbitos regional, nacional e internacional puede propiciar la articulación del potencial biotecnológico del aceite esencial de Lippia alba en contextos agroindustrial e industrial para intervenir problemáticas en salud pública y potenciar las industrias pesquera y agroalimentaria.
dc.description.abstractA descriptive study was developed with the purpose of determining the lines of biotechnological applicability of essential oils of Lippia alba through the integrated analysis of technological surveillance. The methodology included a systematic exploratory review of scientific articles in the EBSCO, Embase, PubMed, Scopus, SciELO and Lilacs databases, and the search for patents in commercial and free databases. Information obtained was analyzed using the Mendeley®, Zotero® bibliographic managers, the Microsoft Excel® 2016 programs, GraphPrad® version 7, Paint3D®, and the IBM SPSS® statistical package version 23.0. The results indicate that essential oils are subjects of interest in the scientific community since the 1990s, and that Brazil (60.5%), Colombia (25.2%) and India (6.2%) are the countries that bet more to this type of research to solve problems in the biomedical and agroindustrial sectors. Researchers have evaluated a wide variety of organisms and microorganisms on which the essential oils of Lippia alba have biological effects. It was also identified by following patents that the main stakeholders interested in the industrialization of this aromatic species are in Brazil, the United States, Japan, France, Canada and India, and they are focused on the development of technologies to respond to the demands related to categories A (current needs of life) and C (chemistry, metallurgy). Lippia alba is a promising medicinal plant in Latin America, it is included in the Vademécum colombiano de plantas medicinales (Colombian Vademecum of Medicinal Plants) and is an over-the-counter drug with approval as an antiseptic for external use in human beings. The market for medicinal plants is underdeveloped in Colombia and its greatest movement is through informal markets, this is why it is difficult to include native species and their derivatives in international markets. However, the generation of strategic alliances with key stakeholders at the regional, national and international spheres can raise and manage the possibilities of articulation of the biotechnological potential of the essential oil of Lippia alba in agroindustrial and industrial contexts with approaches to solve the problems in the public health and strengthen the fishery and agri-food industries.
dc.languagespa
dc.relationPlantlife International, Vines G. Plantlife. Herbal Harvests with a Future – Towards Sustainable Sources for Medicinal Plants. 2004. p. 12. Diponible en: https://goo.gl/N66iRp.
dc.relationGrand view research. market research report. Organic Personal Care Market Size, Share & Trends Analysis Report By Application (Skin Care, Hair Care, Cosmetics, Oral Care), By Region (North America, Europe, APAC, CSA, MEA), and Segment Forecasts, 2018 - 2025. 2018. p. 187. Disponible en: https://bit.ly/2S1bL8T.
dc.relationBouyahya A, Guaouguaou F, Nadia Dakka N, Bakri Y, Dakka N, Bakri Y. Pharmacological activities and medicinal properties of endemic Moroccan medicinal plant Origanum compactum (Benth) and their main compounds. Asian Pacific J Trop Dis. 2017;7(10):628–40.
dc.relationTofiño-Rivera A, Ortega-cuadros M, Melo-Ríos A, Mier-Giraldo H. Vigilancia tecnológica de plantas aromáticas: desde la investigación a la consolidación de la agrocadena colombiana. Corpoica Cienc y Tecnol Agropecu. 2017;18(2):353–77
dc.relationMinAgricultura. Cadena productiva de plantas aromaticas, medicinales, condimentarias y afines (PAMC). Bogotá, Colombia; 2014. Disponible en: https://bit.ly/2Uzwi6d.
dc.relationBernal H, García H, Londoño C, Molano M, Quevedo G, Vásquez C. Pautas para el conocimiento, conservación y uso sostenible de las plantas medicinales nativas en Colombia. 1ra ed.; 2011. 236 p. Disponible en: http://bit.ly/2w60mvG.
dc.relationFajardo S, Lizcano P. Estudio exploratorio de mercado para Lippia alba como alternativa de producción sostenible en la cuenca media y baja del Rio Las Ceibas, 82 Neiva Colombia. Rev Ing y Región. 2015;13 (1):125–37.
dc.relationBarrientos J, Reina M, Chacón M. Potencial económico de cuatro especies aromáticas promisorias para producir aceites esenciales en Colombia. Rev Colomb Ciencias Hortícolas. 2012;6(2):225–37.
dc.relationCardona J, Barrientos J. Producción, uso y comercialización de especies aromáticas en la región Sumapaz, Cundinamarca. Rev Colomb Ciencias Hortícolas. 2015;5(1):114–29.
dc.relationLinde G, Colauto N, Albertó E, Gazim Z. Quimiotipos, Extracción, Composición y Aplicaciones del Aceite Esencial de Lippia alba. Rev bras plantas med. 2016;18(1):191–200.
dc.relationOlivero-Verbel J, González-Cervera T, Güette-Fernandez J, Jaramillo-Colorado B, Stashenko E. Chemical composition and antioxidant activity of essential oils isolated from Colombian plants. Brazilian J Pharmacogn. 2010;20(4):568–74.
dc.relationRamírez L, Castaño D. Metodologías para evaluar in vitro la actividad antibacteriana de compuestos de origen vegetal. Sci Tech Año XV. 2009;(42):263–8.
dc.relationSangwan N, Farooqi A, Shabih F, Sangwan R. Regulation of essential oil production in plants. Plant Growth Regul. 2001; 34:3–21.
dc.relationMinAgricultura. Ingredientes Naturales: Una alternativa de desarrollo rural sostenible. Villavicencio, Colombia; 2014. Disponible en: https://bit.ly/2Uya700,
dc.relationMier H. Cadena Plantas Aromáticas, Medicinales, Condimentarias y Afines. Estrategias para incrementar exportaciones de hierbas aromaticas y condimentarias colombianas. Bogotá, Colombia; 2014. Disponible en: https://bit.ly/2Y00CZB.
dc.relationCorpoica, MinAgricultura, Colciencias. Plan Estratégico de Ciencia, Tecnología e Innovación del Sector Agropecuario Colombiano. Cadena de Plan Estratégico de Ciencia, Tecnología e Innovación del Sector Agropecuario Colombiano. Bogota, Colombia; 2016. Disponible en: https://bit.ly/2EXxABo
dc.relationHennebelle T, Sahpaz S, Joseph H, Bailleul F. Ethnopharmacology of Lippia alba. J Ethnopharmacol. 2008;116(2):211–22.
dc.relationMinisterio de la Protección Social. Vademécum Colombiano de Plantas Medicinales. Bogota, Colombia; 2008. Disponible en: https://bit.ly/2UGvNXD.
dc.relationInvima. Listado de Plantas Medicinales Aceptadas con Fines Terapéuticos diciembre - 2018. 2018. p. 1–69. Disponible en: https://bit.ly/2HmGxb0.
dc.relationAhuja K, Singh S. Global market insights. Essential Oils Market worth over $13 bn by 2024. 2018. Disponible en: https://bit.ly/2TE0LDF.
dc.relationMarkets and Markets. Essential Oils Market by Product Type (Orange, Lemon, Lime, Peppermint, Citronella, Jasmine), Method of Extraction, Application (Food & Beverage, Cosmetics & Toiletries, Aromatherapy, Home Care, Health Care), and Region - Global Forecast to 2022. 2018. Disponible en: https://bit.ly/2T6lFpK
dc.relationDepartamento Administrativo Nacional de Estadística, Departamento Administrativo Nacional de Estadística (DANE). 3 Censo Nacional Agropecuario. Tomo II. Tercer Censo Nacional Agropecuario - 2014 -3er CNA. Bogotá, Colombia; 2016. Disponible en: http://bit.ly/2g3NoH0.
dc.relationStashenko E, Martínez J, Durán D, Córdoba Y, Caballero D. Estudio comparativo de la composición química y la actividad antioxidante de los aceites esenciales de algunas plantas del género Lippia (Verbenaceae) cultivadas en 84 Colombia. Rev Acad Colomb Cienc. 2014;38:89–105
dc.relationEscobar P, Leal S, Herrera L, Martinez J, Stashenko E. Chemical composition and antiprotozoal activities of Colombian Lippia spp essential oils and their major components. Mem Inst Oswaldo Cruz. 2010;105(2):184–90
dc.relationLozada B, Herrera L, Perea J, Stashenko E, Escobar P. Efecto in vitro de aceites esenciales de tres especies de Lippia sobre Moniliophthora roreri (Cif. y Par.) Evans et al., agente causante de la moniliasis del cacao (Theobroma cacao L.). Acta Agron. 2012;61(2):102–10.
dc.relationTofiño-Rivera A, Ortega-Cuadros M, Galvis-Pareja D, Jimenez-Rios H, Merini L, Martinez-Pabon M. Effect of Lippia alba and Cymbopogon citratus essential oils on biofilms of Streptococcus mutans and cytotoxicity in CHO cells. J Ethnopharmacol. 2016;194(2016):749–54.
dc.relationAgudelo-Gómez L, Gómez Ríos G, Durán García D, Stashenko E, BetancurGalvis L. Composición química y evaluación de la actividad antiherpética in vitro de aceites esenciales de Lippia alba (Mill) N.E. Brown y sus componentes mayoritarios. Rev la Univ Ind Santander Salud. 2010;42(3):230–9
dc.relationBonilla C, Sánchez S, Guzman S. El Cultivo de Pronto Alivio Lippia alba (Miller.) N.E. Browm ex Britton & Wilson. Palmira; 2004. 16 p. Disponible en: http://bdigital.unal.edu.co/5409/.
dc.relationBonilla C, Sánchez M, Delgado J, Zambrano E, Buitrago L, Castro D. Descripción botánica, manejo del cultivo y poscosecha de Lippia alba (Mill.) N. E. Brown ex Britton & P. Wilson. 1ra ed. Bogotá: Universidad Nacional de Colombia; 2013. 30 p.
dc.relationBriceño L, Mahecha A, Triana M. Recuperación etnobotánica del uso tradicional no maderable del bosque secundario en el municipio de Nocaima, Cundinamarca. Rev Mutis. 2017;7(1):48–66.
dc.relationRodríguez E, Chepe L, Valencia E. Estudio Etnobotánico de Especies Medicinales Utilizadas por la Comunidad de la Vereda Campo Alegre del Corregimiento De Siberia – Cauca (Colombia). Rev Ciencias. 2013;17(2):35–49
dc.relationOcampo RÁ, Valverde R. Manual de cultivo y conservacion de plantas medicinales. Tomo I. 1ra ed. San josé, Costa Rica: Tramil, Centroamerica; 2000. 152 p.
dc.relationFuentes V, Ciro L, Rodriguez C, Germosén-Robineau L. Manual de cultivo y conservación de plantas medicinales. Tomo II. 1ra ed. Centenario S., editor. Cuba; 2000. 204 p.
dc.relationHernández H, Bonilla C, Sánchez O. Efecto de la fertilización nitrogenada en la producción de biomasa y calidad de aceite esencial en Lippia alba (Miller), Pronto alivio. Acta Agronómica. 2004;53(1):1–7.
dc.relationCos P, Vlietinck A, Berghe D Vanden, Maes L. Anti-infective potential of natural products: How to develop a stronger in vitro “proof-of-concept.” J Ethnopharmacol. 2006;106(3):290–302.
dc.relationButler M. Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep. 2008;25(3):475–516.
dc.relationLang G, Buchbauer G. A review on recent research results (2008-2010) on essential oils as antimicrobials and antifungals. A review. Flavour Fragr J. 2012;27(1):13–39
dc.relationCalsamiglia S, Busquet M, Cardozo P, Castillejos L, Ferret A. Essential oils as modifiers of rumen microbial fermentation. J Dairy Sci. 2007; 90:2580–95.
dc.relationReyes-Jurado, F; Palou, E; López-Malo A. Vapores de aceites esenciales: alternativas de antimicrobianos naturales. Temas Sel Ing Aliment. 2012;6(1):29– 39.
dc.relationNadeem F, Azeem M, Jilani M. Isolation of Bioactive Compounds from Essential Oils – A Comprehensive Review. Int J Chem Biochem Sci. 2017;12:75– 85.
dc.relationLahlou M. Methods to Study the Phytochemistry and Bioactivity of Essential Oils. Phyther Res. 2004; 18:435–48.
dc.relationZhang Q, Lin L, Ye W. Techniques for extraction and isolation of natural products: A comprehensive review. Chin Med. 2018;13(1):1–26.
dc.relationJirovets L, Buchbauer G. Processing of the essential oil plant, in Processing, Analysis and Application of Essential Oils. India: Har Krishan Bhalla & Sons; 2005. 23 p.
dc.relationSaad N, Muller C, Lobstein A. Major bioactivities and mechanism of action of essential oils and their components. Flavour Fragr J. 2013;28(5):269–79.
dc.relationPasqua R, Hoskins N, Betts G, Mauriello G. Changes in membrane fatty acids composition of microbial cells induced by addiction of thymol, carvacrol, limonene, cinnamaldehyde, and eugenol in the growing media. J Agric Food Chem. 2006;54(7):2745–9.
dc.relationLi C-M, Yu J-P. Chemical Composition, Antimicrobial Activity and Mechanism of Action of Essential Oil from the Leaves of M acleaya Cordata (Willd.) R. Br. J Food Saf. 2015;35(2):1-10.
dc.relationArmstrong R, Hall B, Doyle J, Waters E. “Scoping the scope” of a cochrane review. J Public Health (Bangkok). 2011;33(1):147–50.
dc.relationSilva N, Fernandes A. Biological properties of medicinal plants: a review of their antimicrobial activity. J Venom Anim Toxins Incl Trop Dis. 2010;16(3):402– 13
dc.relationLópez M, Stashenko E, Fuentes J. Chemical composition and antigenotoxic properties of Lippia alba essential oils. Genet Mol Biol. 2011;34(3):479–88.
dc.relationOlivero-Verbel J, Güette-Fernandez J, Stashenko E. Acute toxicity against Artemia franciscana of essential oils isolated from plants of the genus Lippia and Piper collected in Colombia. Bol Latinoam y del Caribe Plantas Med y Aromat. 2009;8(5):419–27.
dc.relationOlivero-Verbel J, Guerrero-Castilla A, Stashenko E. Toxicity of the essential oil of the cytral chemotype of Lippia alba (Mill.) N. E. Brown. Acta toxicol argent. 2010;18(1):21–7.
dc.relationMeneses R, Ocazionez R, Martínez J, Stashenko E. Inhibitory effect of essential oils obtained from plants grown in Colombia on yellow fever virus replication in vitro. Ann Clin Microbiol Antimicrob. 2009;8(8):8.
dc.relationMoreno É, Leal S, Stashenko E, García T. Induction of programmed cell death in Trypanosoma cruzi by Lippia alba essential oils and their major and synergistic terpenes (citral, limonene and caryophyllene oxide). BMC Complement Altern Med. 2018;18(1):225.
dc.relationZapata B, Betancur-Galvis L, Duran C, Stashenko E. Cytotoxic activity of Asteraceae and Verbenaceae family essential oils. J Essent Oil Res. 2013;26(1):50–7.
dc.relationGomide M, Lemos F, Lopes M, Alves T, Viccini L, Coelho C. The effect of the essential oils from five different Lippia species on the viability of tumor cell lines. Rev Bras Farmacogn. 2013;23(2013):895–902.
dc.relationViana G, Vale T, Silva C, Matos F. Anticonvulsant activity of essential oils and active principles from chemotypes of Lippia alba (Mill.) N.E. Brown. Biol Pharm Bull. 2000;23(11):1314–7.
dc.relationBlanco M, Colareda G, Baren C, Bandoni A, Ringuelet J, Consolini A. Antispasmodic effects and composition of the essential oils from two South American chemotypes of Lippia alba. J Ethnopharmacol. 2013;149(3):803–9.
dc.relationSousa D, Sousa S, Silva R, Silva-Alves K, Ferreira-da-Silva F, Kerntopf M, et al. Essential oil of Lippia alba and its main constituent citral block the excitability of rat sciatic nerves. Brazilian J Med Biol Res. 2015;48(8):697–702.
dc.relationSilva R, Morais L, Silva A, Bastos C, Pereira-Gonçalves Á, Kerntopf M, et al. Vasorelaxant effect of the Lippia alba essential oil and its major constituent, citral, on the contractility of isolated rat aorta. Biomed Pharmacother. 2018;108
dc.relationCarvalho P, Macêdo C, Ribeiro T, Silva A, Silva R, Morais L, et al. Effect of the Lippia alba (Mill.) N.E. Brown essential oil and its main constituents, citral and limonene, on the tracheal smooth muscle of rats. Biotechnol Reports. 2018; 17:31-34
dc.relationMaynard L, Santos K, Cunha P, Barreto A, Peixoto M, Arrigoni-Blank F, et al. Chemical composition and vasorelaxant effect induced by the essential oil of Lippia alba (Mill.) N.E. Brown. (Verbenaceae) in rat mesenteric artery. Indian J Pharmacol. 2011;43(6):694–8.
dc.relationHatano V, Torricelli A, Giassi A, Coslope L, Viana M. Anxiolytic effects of repeated treatment with an essential oil from Lippia alba and (R)-(-)-carvone in the elevated T-maze. Brazilian J Med Biol Res. 2012;45(3):238–43.
dc.relationJunior G, Abreu M, Rosa J, Pinheiro C, Heinzmann B, Caron B, et al. Lippia alba and Aloysia triphylla essential oils are anxiolytic without inducing aversiveness in fish. Aquaculture. 2018;482 (2018):49–56.
dc.relationSepúlveda-Arias J, Veloza L, Escobar L, Orozco L, Lopera I. Anti-inflammatory effects of the main constituents and epoxides derived from the essential oils obtained from Tagetes lucida, Cymbopogon citratus, Lippia alba and Eucalyptus citriodora. J Essent Oil Res. 2013;25 (3):186–93.
dc.relationSalbego J, Maia J, Toni C, Rodrigues A, Sousa E, Silva L, et al. Anesthesia and sedation of map treefrog (Hypsiboas geographicus) tadpoles with essential oils. Ciência Rural. 2017;47 (11):1–6.
dc.relationStashenko E, Jaramillo E, Martı́nez J. Comparison of different extraction methods for the analysis of volatile secondary metabolites of Lippia alba (Mill.) N.E. Brown, grown in Colombia, and evaluation of its in vitro antioxidant activity. J Chromatogr A. 2004;1025 (1):93–103.
dc.relationSilva L, de Carvalho J, Peixoto M, Blank A, Borges L, Costa Junior L, et al. Assessment of the repellent effect of Lippia alba essential oil and major monoterpenes on the cattle tick Rhipicephalus microplus. Med Vet Entomol. 2016;30 (1):73–7.
dc.relationPeixoto M, Costa-Júnior L, Blank A, Lima A, Menezes T, Santos D, et al. Acaricidal activity of essential oils from Lippia alba genotypes and its major components carvone, limonene, and citral against Rhipicephalus microplus. Vet Parasitol. 2015 May;210(1–2):118–22.
dc.relationChagas A, Oliveira M, Giglioti R, Santana R, Bizzo H, Gama P, et al. Efficacy of 11 Brazilian essential oils on lethality of the cattle tick Rhipicephalus (Boophilus) microplus. Ticks Tick Borne Dis. 2016;7(3):427–32.
dc.relationCaballero-Gallardo K, Olivero-Verbel J, Stashenko E. Repellent activity of essential oils and some of their individual constituents against Tribolium castaneum herbst. J Agric Food Chem. 2011;59(5):1690–6. 90 Peixoto M, Bacci L, Fitzgerald A, Araújo A, Alves P, Silva J, et al. Toxicity and repellency of essential oils of Lippia alba chemotypes and their major monoterpenes against stored grain insects. Ind Crops Prod. 2015;71(2015):31– 6.
dc.relationCastillo R, Stashenko E, Duque J. Insecticidal and Repellent Activity of Several Plant-Derived Essential Oils Against Aedes aegypti. J Am Mosq Control Assoc. 2017;33(1):25–35.
dc.relationRíos N, Stashenko E, Duque J. Evaluation of the insecticidal activity of essential oils and their mixtures against Aedes aegypti (Diptera: Culicidae). Rev Bras Entomol. 2017;61(4):307–11.
dc.relationAldana F, Cruz S. Larvicidal activity of essential oils of Lippia alba and Lippia graveolens, on Aedes aegypti L. Rev Cient. 2017;26(2):36–48.
dc.relationOcazionez R, Meneses R, Torres F, Stashenko E. Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro. Mem Inst Oswaldo Cruz. 2010;105(3):304–9.
dc.relationGomes I, Scher R, Brittes, Rocha L, Vilaca E, Cabral S, et al. Amebicidal activity of the essential oils of Lippia spp. (Verbenaceae) against Acanthamoeba polyphaga trophozoites. Parasitol Res. 2016;115(2):535–40.
dc.relationBaldissera M, Freitas C, Mourão R, Silva L, Monteiro S. Trypanocidal action of Lippia alba and Lippia origanoides essential oils against Trypanosoma evansi in vitro and in vivo used mice as experimental model. J Parasit Dis. 2017;41(2):345–51.
dc.relationMoreira F, Santos C, Innecco R. Hatching and mortality of second-stage juveniles of Meloidogyne incognita race 2 in essential plant oils. Rev Cienc Agron. 2009;40(3):441–8.
dc.relationJuiz P, Lucchese A, Gambari R, Piva R, Penolazzi L, Di Ciano M, et al. Essential oils and isolated compounds from Lippia alba leaves and flowers: Antimicrobial activity and osteoclast apoptosis. Int J Mol Med. 2015;35(1):211–7.
dc.relationBersan S, Galvão L, Goes V, Sartoratto A, Figueira G, Rehder V, et al. Action of essential oils from Brazilian native and exotic medicinal species on oral biofilms. BMC Complement Altern Med. 2014 Jan;14(1):1–12.
dc.relationMachado T, Nogueira N, Pereira R, de Sousa C, Batista V. The antimicrobial efficacy of Lippia alba essential oil and its interaction with food ingredients. Braz J Microbiol. 2014;45(2):699–705.
dc.relationCosta D, Vermelho A, Almeida C, Dias E, Cedrola S, Arrigoni-Blank M et al., Inhibitory effect of linalool-rich essential oil from Lippia alba on the peptidase and keratinase activities of dermatophytes. J Enzyme Inhib Med Chem. 2014;29(1):12–7.
dc.relationTangarife-Castaño V, Roa-Linares V, Betancur-Galvis L, Durán García D, Stashenko E, Mesa-Arango A, et al. Antifungal activity of Verbenaceae ancl Labiatae families essential oils. Pharmacologyonline. 2012;1(SPL. 1):133–45
dc.relationAnaruma N, Schmidt F, Duarte M, Figueira G, Delarmelina C, Benato E, et al. Control of Colletotrichum gloeosporioides (penz.) Sacc. In yellow passion fruit using Cymbopogon citratus essential oil. Brazilian J Microbiol. 2010;41(1):66–73.
dc.relationSouza P, Goulart F, Marques J, Bizzo H, Blank A, Groposo C, et al. Growth Inhibition of Sulfate-Reducing Bacteria in Produced Water from the Petroleum Industry Using Essential Oils. Molecules. 2017;22(4):1–10.
dc.relationSouza R, Costa M, Baldisserotto B, Heinzmann B, Schmidt D, Caron B, et al. Antimicrobial and synergistic activity of essential oils of Aloysia triphylla and Lippia alba against Aeromonas spp. Microb Pathog. 2017;113(2017):29–33
dc.relationMajolo C, Rocha S, Chagas E, Chaves F, Bizzo H. Chemical composition of Lippia spp. essential oil and antimicrobial activity against Aeromonas hydrophila. Aquac Res. 2017;48(5):1–8.
dc.relationSutili F, Cunha M, Ziech R, Krewer C, Zeppenfeld C, Heldwein C, et al. Lippia alba essential oil promotes survival of silver catfish (Rhamdia quelen) infected with Aeromonas sp. An Acad Bras Cienc. 2015;87(1):95–100.
dc.relationMesa-Arango A, Betancur-Galvis L, Montiel J, Bueno J, Baena A, Durán D, et al. Antifungal activity and chemical composition of the essential oils of Lippia alba (Miller) n.e brown grown in different regions of colombia. J Essent Oil Res. 2010;22(6):568–74.
dc.relationSantos N, Pascon R, Vallim M, Figueiredo C, Soares M, Lago J, et al. Cytotoxic and Antimicrobial Constituents from the Essential Oil of Lippia alba (Verbenaceae). Med (Basel, Switzerland). 2016;3(3):2–9.
dc.relationMesa-Arango A, Montiel-Ramos J, Zapata B, Durán C, Betancur-Galvis L, Stashenko E. Citral and carvone chemotypes from the essential oils of Colombian Lippia alba (Mill.) N.E. Brown: composition, cytotoxicity and antifungal activity. Mem Inst Oswaldo Cruz. 2009 Sep;104(6):878–84.
dc.relationGlamočlija J, Soković M, Tešević V, Linde G, Colauto N. Chemical characterization of Lippia alba essential oil: an alternative to control green molds. Brazilian J Microbiol. 2011;42(4):1537–46.
dc.relationPorfírio E, Melo H, Matheus A, Pereira G, Thays T, Cavalcante A, et al. In Vitro Antibacterial and Antibiofilm Activity of Lippia alba Essential Oil, Citral, and Carvone against Staphylococcus aureus. Sci World J. 2017; 2017:1-7
dc.relationDuarte M, Leme E, Delarmelina C, Soares A, Figueira G, Sartoratto A. Activity of essential oils from Brazilian medicinal plants on Escherichia coli. J Ethnopharmacol. 2007;111(2):197–201.
dc.relationDuarte M, Figueira G, Sartoratto A, Rehder V, Delarmelina C. Anti-Candida activity of Brazilian medicinal plants. J Ethnopharmacol. 2005;97(2):305–11. 119 Shukla R, Kumar A, Singh P, Dubey N. Efficacy of Lippia alba (Mill.) N.E. Brown essential oil and its monoterpene aldehyde constituents against fungi isolated from some edible legume seeds and aflatoxin B1 production. Int J Food Microbiol. 2009;135(2):165–70.
dc.relationCunha M, Silva B, Delunardo F, Benovit S, Gomes L, Heinzmann B, et al. Anesthetic induction and recovery of Hippocampus reidi exposed to the essential oil of Lippia alba. Neotrop Ichthyol. 2011;9(3):683–8.
dc.relationSimões L, Campos L, Heinzmann B, Loro V, Carvalho L, Silva D, et al. Essential oil of Lippia alba as a sedative and anesthetic for the sea urchin Echinometra lucunter (Linnaeus, 1758). Mar Freshw Behav Physiol. 2017;50(3):205–17.
dc.relationParodi T, Cunha M, Heldwein C, De Souza D, Martins A, Garcia L, et al. The anesthetic efficacy of eugenol and the essential oils of Lippia alba and Aloysia triphylla in post-larvae and sub-adults of Litopenaeus vannamei (Crustacea, Penaeidae). Comp Biochem Physiol - C Toxicol Pharmacol. 2012;155(3):462–8.
dc.relationSena A, Teixeira R, Ferreira E, Heinzmann B, Baldisserotto B, Caron B, et al. Essential oil from Lippia alba has anaesthetic activity and is effective in reducing handling and transport stress in tambacu (Piaractus mesopotamicus × Colossoma macropomum). Aquaculture. 2016;465(2016):374–9.
dc.relationHohlenwerger J, Baldisserotto B, Couto R, Heinzmann B, da Silva D, Caron B, et al. Essential oil of Lippia alba in the transport of Nile tilapia | Óleo essencial de Lippia alba no transporte de tilápia-do-Nilo. Cienc Rural. 2017;47(3):1–4.
dc.relationCunha M, de Barros F, de Oliveira G, de Lima A, Heinzmann B, Loro L, et al. Essential oil of Lippia alba: A new anesthetic for silver catfish, Rhamdia quelen. Aquaculture. 2010;306(1–4):403–6.
dc.relationSalbego J, Toni C, Becker A, Zeppenfeld C, Menezes C, Loro V, et al. Biochemical parameters of silver catfish (Rhamdia quelen) after transport with eugenol or essential oil of Lippia alba added to the water. Brazilian J Biol. 2017;77(4):696–702. A.
dc.relationLima A, Daniel A, Klein B, Quatrin A, de Souza Rezer A, Milani L, et al. Chemical, microbiological, and sensory parameters during the refrigerated storage of silver catfish (Rhamdia quelen) exposed in vivo to the essential oil of Lippia alba. J Food Sci Technol. 2018;55(4):1416–25.
dc.relationSantos E, Brandão F, Majolo C, Inoue L, Maciel P, de Oliveira M, et al. Lippia alba essential oil as anesthetic for tambaqui. Aquaculture. 2018;495(2018):545– 9.
dc.relationToni C, Becker A, Simões L, Pinheiro C, de Lima L, Heinzmann B, et al. Fish anesthesia: Effects of the essential oils of Hesperozygis ringens and Lippia alba on the biochemistry and physiology of silver catfish (Rhamdia quelen). Fish Physiol Biochem. 2014;40(3):701–14.
dc.relationVeit J, Piccolo J, Scherer A, Machado I, Peres M, Schwerz J, et al. Stability of frozen fillets from silver catfish anesthetized with essential oil of Lippia alba prior to electrical stunning or hypothermia. J Food Process Preserv. 2017;41(5):1–10.
dc.relationCárdenas C, Toni C, Martos-Sitcha J, Cárdenas S, de las Heras V, Baldisserotto B, et al. Effects of clove oil, essential oil of Lippia alba and 2-phe anaesthesia on juvenile meagre, Argyrosomus regius (Asso, 1801). J Appl Ichthyol. 2016;32(4):693–700.
dc.relationAlmeida A, Heinzmann B, Val A, Baldisserotto B. Essential oils and eugenol as anesthetics for serrasalmus rhombeus. Bol do Inst Pesca. 2018;44(1):44–50.
dc.relationToni C, Martos-Sitcha J, Baldisserotto B, Heinzmann B, Lima L, MartínezRodríguez G, et al. Sedative effect of 2-phenoxyethanol and essential oil of Lippia alba on stress response in gilthead sea bream (Sparus aurata). Res Vet Sci. 2015; 103:20–7
dc.relationAzambuja C, Mattiazzi J, Riffel A, Finamor I, Garcia L, Heldwein C, et al. Effect of the essential oil of Lippia alba on oxidative stress parameters in silver catfish (Rhamdia quelen) subjected to transport. Aquaculture. 2011;319(1– 2):156–61.
dc.relationVeeck A, Klein B, Ferreira L, Becker A, Heldwein C, Heinzmann B, et al. Lipid stability during the frozen storage of fillets from silver catfish exposed in vivo to the essential oil of Lippia alba (Mill.) NE Brown. J Sci Food Agric. 2013;93(4):955–60.
dc.relationSalbego J, Becker A, Gonçalves J, Menezes C, Heldwein C, Spanevello R, et al. The essential oil from Lippia alba induces biochemical stress in the silver catfish (Rhamdia quelen) after transportation. Neotrop ichthyol. 2014;12(4):811–
dc.relationSoares B, Neves L, Oliveira M, Chaves F, Dias M, Chagas E, et al. Antiparasitic activity of the essential oil of Lippia alba on ectoparasites of Colossoma macropomum (tambaqui) and its physiological and histopathological effects. Aquaculture. 2016;452(2016):107–14.
dc.relationSouza C, Lima T, Baldissera M, Geihs M, Maciel F, Nery L, et al. Nanoencapsulated Melaleuca alternifolia essential oil exerts anesthetic effects in the brachyuran crab using Neohelice granulate. An Acad Bras Cienc. 2018;90(3):2855–64.
dc.relationRodrigues-Soares J, Jesus G, Gonçalves E, Moraes K, Chagas E, Chaves F, et al. Induced aerocystitis and hemato-immunological parameters in nile tilapia fed supplemented diet with essential oil of Lippia alba. Brazilian J Vet Res Anim Sci. 2018;55(1):1–12.
dc.relationBermúdez-Cañete M. Uso Industrial de Plantas Aromáticas y Medicinales. Tema 7. Aceites esenciales. 2010. p. 10. Disponible en: https://bit.ly/2XWSaul.
dc.relationStashenko E, Jaramillo B, Martínez J. Comparación de la composición química y de la actividad antioxidante in vitro de los metabolitos secundarios volátiles de plantas de la familia verbenaceae. Rev Acad Colomb Cienc. 2003;27(105):579–97.
dc.relationGómez G, Durán D, Martínez J, Stashenko E, Verbel J. Comparación de la composición química y de la actividad biológica de los aceites esenciales de Lippia alba (mill.) n.e.br., obtenidos variando las condiciones de extracción y secado. Sci Tech. 2007; XIII (33):227–9.
dc.relationBandoni A. Los Recursos Vegetales Aromáticos en Latinoamérica. UNLP-CYTED, editor. Buenos aires; 2000. 410 p.
dc.relationDurán D, Monsalve L, Martínez J, Stashenko E. Estudio comparativo de la composición química de aceites esenciales de Lippia alba provenientes de diferentes regiones de Colombia, y efecto del tiempo de destilación sobre la composición del aceite. Sci Tech Año XIII. 2007; 33:435–8.
dc.relationLopez-Romero J, González-Ríos H, Borges A, Simões M. Antibacterial Effects and Mode of Action of Selected Essential Oils Components against Escherichia coli and Staphylococcus aureus. Evid Based Complement Alternat Med; 2015:795435.
dc.relationAENOR. Norma española UNE 166002. Gestión de la I+D+i: Requisitos del Sistema de Gestión de la I+D+i. 2006. p. 24. Disponible en: https://bit.ly/2YmVC1A.
dc.relationGonzález A, Gómez D. Guía Práctica InnoViTech. Rionegro, Antioquia; 2015.
dc.relationMarulanda C, Hernández A, López M. Vigilancia tecnológica para estudiantes universitarios. El caso de la universidad nacional de Colombia, sede manizales. Form Univ. 2016;9(2):17–28.
dc.relationAguirre J, Cataño G, Roja M. Análisis prospectivo de oportunidades de negocios basados en vigilancia tecnológica. Puente. 2013;7(1):29–39. Disponible en: http://bit.ly/2VKKTjU
dc.relationLeón A, Castellanos O, Vargas F. Valoración, selección y pertinencia de herramientas de software utilizadas en vigilancia tecnológica. Rev Ing E Investig. 2006;26(1):92–102.
dc.relationVarón C. Gestores bibliográficos: recomendaciones para su aprovechamiento en la academia. 2017. Disponible en: http://bit.ly/2Q6fu56.
dc.relationDíaz-Pérez M, de Moya-Anegón F. El análisis de patentes como estrategia para la toma de decisiones innovadoras. El Prof la Inf. 2008;17(3):293–302.
dc.relationOrganizacion Mundial de la Propiedad Intelectual. Las patentes: fuente de información. Ginebra; 2015. Disponible en: https://bit.ly/2ElKsDA.
dc.relationVera A, Olivero J, Jaramillo B, Stashenko E. Efecto protector del aceite esencial de Lippia alba (Mill.) N.E.: Brown sobre la toxicidad del mercurocromo en raíces de Allium cepa L. Rev Cuba Plantas. 2010;15(1):27–37.
dc.relationNeira L, Mantilla J, Stashenko E, Escobar P. Toxicidad, genotoxicidad y actividad anti-Leishmania de aceites esenciales obtenidos de cuatro (4) quimiotipos del género Lippia. Bol Latinoam y del Caribe Plantas Med y Aromat. 2018;17(1):68–83
dc.relationAular Y, Villamizar M, Pérez Y, Pérez V. Composición química y toxicidad aguda oral del aceite esencial de Lippia alba en ratones. Salus. 2016;20(1):43– 51.
dc.relationFauth S, Campos A, Silveira E, Rao V. Efeitos de óleos essenciais de plantas no tempo de sono induzido por cetamina em camundongos. Rev bras Farm. 2002;12(supl.1):112–3.
dc.relationVera S, Zambrano D, Méndez-Sanchez S, Rodríguez-Sanabria F, Stashenko E, Duque J. Essential oils with insecticidal activity against larvae of Aedes aegypti (Diptera: Culicidae). Parasitol Res. 2014;113(7):2647–54.
dc.relationMuñoz J, Staschenko E, Ocampo C. Actividad insecticida de aceites esenciales de plantas nativas contra Aedes aegypti (Diptera: Culicidae). Rev Colomb Entomol. 2014;40(2):198–202.
dc.relationPino J, Ortega A, Rosado A, Rodríguez M, Baluja R. Composición y propiedades antibacterianas del aceite esencial de Lippia alba (Mill.) N.E. Brown. Rev Cuba Farm. 1996;30(1):29–35.
dc.relationMena-Rodríguez E, Ortega-Cuadros M, Merini L, Melo-ríos AE, Tofiño-rivera A. Efecto de agroinsumos y aceites esenciales en el suelo de hortalizas en el Caribe colombiano. Corpoica Cienc y Tecnol Agropecu. 2018;19(1):103–24.
dc.relationFAO- MinAgricultura. Politica integral para el desarrollo de la pesca sostenible en Colombia. Colombia; 2015. Disponible en: http://bit.ly/2w3zkF3
dc.relationMinSalud Lineamiento para la conformación y operacion de los equipos funcionales del programa de promoción, prevención y control de las enfermedades transmitidas por vectores. Bogota, Colombia; 2017. Disponible en: http://bit.ly/30qTjeR.
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectEsencias
dc.subjectPlantas medicinales
dc.subjectPlantas aromáticas
dc.titleAplicabilidad biotecnológica de aceites esenciales de Lippia alba


Este ítem pertenece a la siguiente institución