Modelo de uso de la planta medicinal Bursera Simaruba y su actividad antiinflamatoria

dc.contributorParga Lozano, Carlos Hernando
dc.creatorColey Silva, Luis Fernando
dc.creatorAhumada Navarro, Waldy Enrique
dc.date.accessioned2020-01-31T15:41:27Z
dc.date.available2020-01-31T15:41:27Z
dc.date.created2020-01-31T15:41:27Z
dc.identifierhttps://hdl.handle.net/10901/17816
dc.description.abstractLa actividad antiinflamatoria ha despertado en los últimos años un gran interés científico en el área farmacológica, principalmente en virtud de la capacidad potencial de ciertos metabolitos de interferir en la evolución de enfermedades que cursan con procesos inflamatorios. Dicho proceso involucra una serie de eventos inespecíficos que pueden ser provocados por numerosos estímulos o agresiones del medio. Debido a esto, un número de plantas medicinales han mostrado actividad farmacológica útil, incluyendo efectos antiinflamatorios. Entre estas plantas, Bursera simaruba, es un árbol comúnmente difundido en Venezuela, Belice, Colombia y Centroamérica. En estos países se ha utilizado con éxito para el tratamiento de infecciones locales y sistémicas. De este modo, se busca describir la respuesta inmunomoduladora de los extractos de la planta Bursera simaruba y su aplicabilidad terapéutica en el tratamiento de enfermedades inflamatorias. Por consiguiente, se realizó una revisión de la literatura científica en diferentes bases de datos (PubMed, Scopus y ScienceDirect) con una ruta de búsqueda sencilla. Se encontró que los metabolitos analizados presentaron efectos inhibitorios sobre la expresión de las citoquinas proinflamatorias, de las enzimas mediadoras y los catabolitos. Esta actividad inhibitoria se debió principalmente a la inactivación de la vía NF-κB o a la regulación de algunos factores de transcripción. En conclusión estos resultados sugieren que la planta Bursera simaruba tiene efectos antiinflamatorios y puede ser una opción potencial en el tratamiento de las enfermedades inflamatorias.
dc.description.abstractAnti-inflammatory activity has aroused in recent years a great scientific interest in the pharmacological area, mainly due to the potential capacity of certain metabolites to interfere in the evolution of diseases that occur with inflammatory processes. This process involves a series of nonspecific events that can be caused by numerous stimuli or attacks from the environment. Because of this, a number of medicinal plants have shown useful pharmacological activity, including anti-inflammatory effects. Among these plants, Bursera simaruba, is a tree commonly spread in Venezuela, Belize, Colombia and Central America. In these countries it has been used successfully for the treatment of local and systemic infections. In this way, we seek to describe the immunomodulatory response of the extracts of the Bursera simaruba plant and its therapeutic applicability in the treatment of inflammatory diseases. Therefore, a review of the scientific literature in different databases (PubMed, Scopus and ScienceDirect) was performed with a simple search path. The analyzed metabolites were found to have inhibitory effects on the expression of proinflammatory cytokines, mediating enzymes and catabolites. This inhibitory activity was mainly due to the inactivation of the NF-κB pathway or the regulation of some transcription factors. In conclusion, these results suggest that the Bursera simaruba plant has anti-inflammatory effects and may be a potential option in the treatment of inflammatory diseases.
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dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectPlantas medicinales
dc.subjectTratamiento de enfermedades
dc.subjectMetabolitos
dc.titleModelo de uso de la planta medicinal Bursera Simaruba y su actividad antiinflamatoria


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