Anticoagulantes orales directos: monitorización y reversión, dos grandes dificultades

dc.contributorGonzález Aguirre, Irene
dc.contributorIglesias Acosta, Jesús
dc.creatorCarrillo Navarro, María Claudia
dc.creatorGuerrero García, Augusto Santiago
dc.date.accessioned2017-07-26T19:02:54Z
dc.date.available2017-07-26T19:02:54Z
dc.date.created2017-07-26T19:02:54Z
dc.identifierhttps://hdl.handle.net/10901/10236
dc.identifierinstname:Universidad Libre
dc.identifierreponame:Repositorio Institucional Universidad Libre
dc.description.abstractLa tromboembolia representa una importante causa de morbimortalidad, siendo la anticoagulación el pilar del tratamiento. Los anticoagulantes orales directos, constituyen una opción que supera algunos de los inconvenientes con warfarina, como la monitorización rutinaria. No obstante con su inclusión en la práctica clínica, surgieron otras limitaciones: la dificultad para su medición cuando se requiere, debido a la poca disponibilidad y estandarización de pruebas hemostáticas; y la falta de antídotos para reversión, frente a hemorrágicas severas. Sin embargo recientemente fue aprobado idarucizumab, un anticuerpo monoclonal que neutraliza al dabigatrán, no disponible en Colombia. Se concluye que estos fármacos, son una opción atractiva, que requieren el desarrollo de pruebas diagnósticas y agentes de reversión específicos accesibles. Se realizó una búsqueda en bases de datos como Pubmed, Clinical Key, Embase, Evidence- Based MEDICINE, con las palabras clave dabigatrán, rivaroxabán, apixabán, monitorización, sangrado. Se incluyó literatura en idioma inglés y español entre 1998-2016.
dc.description.abstractThromboembolism is a major cause of morbidity and mortality, with anticoagulation being the mainstay of treatment. The direct oral anticoagulants are an option to overcome some of the drawbacks of warfarin, such as routine monitoring. Nevertheless, new constraints have emerged by their inclusion in clinical practice: the difficulty in measuring, due to the limited availability and standardization of hemostatic tests; and the lack of antidotes for reversal, to deal with severe bleeding. However, idarucizumab was recently approved, it’s a monoclonal antibody that neutralizes dabigatran, but is not available in Colombia. We concluded that these drugs are an attractive option, which require the development of diagnostic tests and available specific reversal agents. We made the research on databases such as Pubmed, Clinical Key, Embase, Evidence-Based Medicine, with keywords dabigatran, rivaroxaban, apixaban, monitoring, bleeding. We include the literature in English and Spanish language between 1998 and 2016.
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dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectAnticoagulantes
dc.subjectTromboembolia
dc.subjectTromboembolia
dc.subjectTromboembolia
dc.subjectMedicamentos
dc.titleAnticoagulantes orales directos: monitorización y reversión, dos grandes dificultades


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