Study on the inhibitory effect of furafylline and troleandomycin in the7-methoxyresorufin-O-demethylase and nifedipine oxidase activitiesin hepatic microsomes from four poultry species usinghigh-performance liquid chromatography coupled with fluorescenceand ultraviolet detection

dc.creatorMurcia, Hansen
dc.creatorCruz, Andrés
dc.creatorLeón, Jeffrey
dc.creatorGonzález-Curbelo, Miguel Ángel
dc.date.accessioned2019-06-18T21:56:13Z
dc.date.accessioned2022-09-28T14:33:33Z
dc.date.available2019-06-18T21:56:13Z
dc.date.available2022-09-28T14:33:33Z
dc.date.created2019-06-18T21:56:13Z
dc.date.issued2018-10-22
dc.identifierMurcia, H., Cruz, A., León, J., & González-Curbelo, M. Á. (2018). Study on the inhibitory effect of furafylline and troleandomycin in the7-methoxyresorufin-O-demethylase and nifedipine oxidase activitiesin hepatic microsomes from four poultry species usinghigh-performance liquid chromatography coupled with fluorescenceand ultraviolet detection. Bogotá: doi:/10.1016/j.jpba.2018.10.031
dc.identifierhttp://hdl.handle.net/11634/17172
dc.identifierhttps://doi.org//10.1016/j.jpba.2018.10.031
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3661236
dc.description.abstracttThe present study reports the in vitro studies with furafylline and troleandomycin (TAO) as specificinhibitors of activities 7-methoxyresorufin-O-demethylase (MROD) and nifedipine oxidase, catalyzed bycytochrome P450 1 A2 (CYP1 A2) and 3A4 human enzymes, respectively, in hepatic microsomes of quail,duck, turkey and chicken. The results suggest that in chicken and quail the MROD activity is carried out byorthologs CYP1 A4 and 1 A5, meanwhile in duck and turkey by a CYP1 A5 ortholog. The nifedipine oxidaseactivity is carried out by orthologs of the CYP3A family in the four bird species. The use of furafyllineand TAO significantly decreased these activities (P < 0.05) and suggested that the biotransformation ofresorufin methyl ether (RME) may be related to more than one avian ortholog.
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dc.rightshttp://creativecommons.org/licenses/by-nc-sa/2.5/co/
dc.rightsAtribución-NoComercial-CompartirIgual 2.5 Colombia
dc.titleStudy on the inhibitory effect of furafylline and troleandomycin in the7-methoxyresorufin-O-demethylase and nifedipine oxidase activitiesin hepatic microsomes from four poultry species usinghigh-performance liquid chromatography coupled with fluorescenceand ultraviolet detection
dc.typeGeneración de Nuevo Conocimiento: Artículos publicados en revistas especializadas - Electrónicos


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