Aplicabilidad de la fibrina rica en plaquetas y leucitos en los diferentes procedimientos endodonticos-Scoping Review

Abstract

Leucocyte platelet-rich fibrin (L-PRF) is part of a new generation of platelet concentrates aimed at a simplified preparation with no biochemical manipulation of blood. It has been proven that it works as a scaffolding, providing a spatially-correct position of the location of cells, regulating the differentiation, proliferation, and/or metabolism of stem cells in the field of regenerative endodontics. Objective: To conduct a scoping review to the application of leucocyte platelet-richfibrin L-PRF in endodontic procedures documented in the literature. Materials and methods: A strategy was designed to search for articles in the last 10 years in which the L-PRF application were described in the endodontic procedures found on the following databases: Pubmed, Epistemonikos, Scielo, and Cochrane. The methodological quality assessment, risk of bias, and the extraction of data were conducted independently and per duplicate. The results were stated using the PRISMA guide. Results: 18 studies were selected, of which 6 were case reports, three case series, four prospective studies, one randomised clinical assay, one in vivo study, one pilot study, one in vitro study, and one retrospective controlled cohort study. The L-PRF applications reported in the literature for endodontic procedures are pulp regeneration, periradicular surgery, direct pulp capping, and pulpotomy. Conclusions: The successful REP result is evaluated or measured as their capacity to achieve apical closure, scarring of periapical lesion, increase in radicular length, and/or thickening of dentinal wall.