Vector-borne transmission of Trypanosoma cruzi among captive Neotropical primates in a Brazilian zoo

dc.creatorSouza, Thaís Tâmara Castro Minuzzi
dc.creatorNitz, Nadjar
dc.creatorKnox, Monique Britto
dc.creatorReis, Felipe
dc.creatorHagström, Luciana
dc.creatorCuba, César Augusto Cuba
dc.creatorHecht, Mariana Machado
dc.creatorGonçalves, Rodrigo Gurgel
dc.date2016-05-18T12:49:25Z
dc.date2016-05-18T12:49:25Z
dc.date2016-01
dc.date.accessioned2017-03-07T13:23:46Z
dc.date.available2017-03-07T13:23:46Z
dc.identifierSOUZA, Thaís Tâmara Castro Minuzzi et al. Vector-borne transmission of Trypanosoma cruzi among captive Neotropical primates in a Brazilian zoo. Parasites & Vectors, v. 9, n. 39, p. 1-6, jan. 2016. Disponível em: <http://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-016-1334-7>. Acesso em: 13 maio 2016. 10.1186/s13071-016-1334-7
dc.identifierhttp://repositorio.unb.br/handle/10482/20301
dc.identifier10.1186/s13071-016-1334-7
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/363049
dc.descriptionBackground: Neotropical primates are important sylvatic hosts of Trypanosoma cruzi, the etiological agent of Chagas disease. Infection is often subclinical, but severe disease has been described in both free-ranging and captive primates. Panstrongylus megistus, a major T. cruzi vector, was found infesting a small-primate unit at Brasília zoo (ZooB), Brazil. ZooB lies close to a gallery-forest patch where T. cruzi circulates naturally. Here, we combine parasitological and molecular methods to investigate a focus of T. cruzi infection involving triatomine bugs and Neotropical primates at a zoo located in the Brazilian Savannah. Methods: We assessed T. cruzi infection in vectors using optical microscopy (n = 34) and nested PCR (n = 50). We used quantitative PCR (qPCR) to examine blood samples from 26 primates and necropsy samples from two primates that died during the study. We determined parasite lineages in five vectors and two primates by comparing glucose-6-phosphate isomerase (G6pi) gene sequences. Results: Trypanosoma cruzi was found in 44 vectors and 17 primates (six genera and eight species); one Mico chrysoleucus and one Saguinus niger had high parasitaemias. Trypanosoma cruzi DNA was detected in three primates born to qPCR-negative mothers at ZooB and in the two dead specimens. One Callithrix geoffroyi became qPCR-positive over a two-year follow-up. All G6pi sequences matched T. cruzi lineage TcI. Conclusions: Our findings strongly suggest vector-borne T. cruzi transmission within a small-primate unit at ZooB – with vectors, and perhaps also parasites, presumably coming from nearby gallery forest. Periodic checks for vectors and parasites would help eliminate T. cruzi transmission foci in captive-animal facilities. This should be of special importance for captive-breeding programs involving endangered mammals, and would reduce the risk of accidental T. cruzi transmission to keepers and veterinarians.
dc.languageeng
dc.rightsOpen Access
dc.rights© 2016 Minuzzi-Souza et al. Open Access This article is distributed under the terms of the Creative Commons (Attribution 4.0 International License), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source. Fonte: http://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-016-1334. Acesso em: 13 maio 2016.
dc.subjectTripanossoma cruzi
dc.subjectJardins zoológicos - Brasília (DF)
dc.subjectPrimatas
dc.subjectBarbeiro (Triatomíneo)
dc.subjectInseto como transmissor de doenças
dc.titleVector-borne transmission of Trypanosoma cruzi among captive Neotropical primates in a Brazilian zoo
dc.typeArtículos de revistas


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