dc.contributor | Masira | |
dc.creator | Wang, Chuangshi | |
dc.creator | Hu, Bo | |
dc.creator | Rangarajan, Sumathy | |
dc.creator | Bangdiwala, Shrikant I. | |
dc.creator | Lear, Scott A. | |
dc.creator | Mohan, Viswanathan | |
dc.creator | Gupta, Rajeev | |
dc.creator | Alhabib, Khalid F. | |
dc.creator | Soman, Biju | |
dc.creator | Abat, Marc Evans M. | |
dc.creator | Rosengren, Annika | |
dc.creator | Lanas, Fernando | |
dc.creator | Avezum, Alvaro | |
dc.creator | Lopez-Jaramillo, Patricio | |
dc.creator | Diaz, Rafael | |
dc.creator | Yusoff, Khalid | |
dc.creator | Iqbal, Romaina | |
dc.creator | Chifamba, Jephat | |
dc.creator | Yeates, Karen | |
dc.creator | Zatońska, Katarzyna | |
dc.creator | Kruger, Iolanthe M. | |
dc.creator | Bahonar, Ahmad | |
dc.creator | Yusufali, AfzalHussein | |
dc.creator | Li, Wei | |
dc.creator | Yusuf, Salim | |
dc.creator | The Prospective Urban Rural Epidemiology (PURE) study investigators | |
dc.date.accessioned | 2022-02-23T15:46:25Z | |
dc.date.available | 2022-02-23T15:46:25Z | |
dc.date.created | 2022-02-23T15:46:25Z | |
dc.date.issued | 2021-04-05 | |
dc.identifier | https://doi.org/10.1016/j.sleep.2021.01.057 | |
dc.identifier | https://repositorio.udes.edu.co/handle/001/6126 | |
dc.description.abstract | Objectives
This study aimed to examine the association of bedtime with mortality and major cardiovascular events.
Methods
Bedtime was recorded based on self-reported habitual time of going to bed in 112,198 participants from 21 countries in the Prospective Urban Rural Epidemiology (PURE) study. Participants were prospectively followed for 9.2 years. We examined the association between bedtime and the composite outcome of all-cause mortality, non-fatal myocardial infarction, stroke and heart failure. Participants with a usual bedtime earlier than 10PM were categorized as ‘earlier’ sleepers and those who reported a bedtime after midnight as ‘later’ sleepers. Cox frailty models were applied with random intercepts to account for the clustering within centers.
Results
A total of 5633 deaths and 5346 major cardiovascular events were reported. A U-shaped association was observed between bedtime and the composite outcome. Using those going to bed between 10PM and midnight as the reference group, after adjustment for age and sex, both earlier and later sleepers had a higher risk of the composite outcome (HR of 1.29 [1.22, 1.35] and 1.11 [1.03, 1.20], respectively). In the fully adjusted model where demographic factors, lifestyle behaviors (including total sleep duration) and history of diseases were included, results were greatly attenuated, but the estimates indicated modestly higher risks in both earlier (HR of 1.09 [1.03–1.16]) and later sleepers (HR of 1.10 [1.02–1.20]).
Conclusion
Early (10 PM or earlier) or late (Midnight or later) bedtimes may be an indicator or risk factor of adverse health outcomes. | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.publisher | Canada | |
dc.relation | 272 | |
dc.relation | 265 | |
dc.relation | 80 | |
dc.relation | Chuangshi Wang, Bo Hu, Sumathy Rangarajan, Shrikant I. Bangdiwala, Scott A. Lear, Viswanathan Mohan, Rajeev Gupta, Khalid F. Alhabib, Biju Soman, Marc Evans M. Abat, Annika Rosengren, Fernando Lanas, Alvaro Avezum, Patricio Lopez-Jaramillo, Rafael Diaz, Khalid Yusoff, Romaina Iqbal, Jephat Chifamba, Karen Yeates, Katarzyna Zatońska, Iolanthé M. Kruger, Ahmad Bahonar, Afzalhussein Yusufali, Wei Li, Salim Yusuf, Association of bedtime with mortality and major cardiovascular events: an analysis of 112,198 individuals from 21 countries in the PURE study, Sleep Medicine, Volume 80, 2021, Pages 265-272, ISSN 1389-9457, https://doi.org/10.1016/j.sleep.2021.01.057. (https://www.sciencedirect.com/science/article/pii/S1389945721000745) | |
dc.relation | Chuangshi Wang, Bo Hu, Sumathy Rangarajan, Shrikant I. Bangdiwala, Sadi Gulec, Scott A. Lear, Viswanathan Mohan, Rajeev Gupta, Khalid F. Alhabib, Biju Soman, Marc Evans M. Abat, Annika Rosengren, Fernando Lanas, Alvaro Avezum, Patricio Lopez-Jaramillo, Rafael Diaz, Khalid Yusoff, Romaina Iqbal, Jephat Chifamba, Karen Yeates, Katarzyna Zatońska, Iolanthé M. Kruger, Ahmad Bahonar, Afzalhussein Yusufali, Wei Li, Salim Yusuf ‘Corrigendum to “Association of bedtime with mortality and major cardiovascular events: an analysis of 112,198 individuals from 21 countries in the PURE study” [Sleep Medicine 80 (2021) 265–272]’ Sleep Medicine, Available online 5 January 2022, Pages | |
dc.relation | Scopus | |
dc.relation | Sleep Medicine | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.rights | Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) | |
dc.rights | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.rights | © 2021 The Authors, Published by Elsevier B.V. | |
dc.source | https://www.sciencedirect.com/science/article/abs/pii/S1389945721000745#! | |
dc.title | Association of bedtime with mortality and major cardiovascular events: an analysis of 112,198 individuals from 21 countries in the PURE study | |
dc.type | Artículo de revista | |