dc.creator | Serrano-Gómez, Silvia | |
dc.creator | Sanabria-Salas, María Carolina | |
dc.creator | Garay, Jone | |
dc.creator | Baddoo, Melody C. | |
dc.creator | Hernández Súarez, Gustavo | |
dc.creator | Mejía, Juan Carlos | |
dc.creator | García, Oscar | |
dc.creator | Miele, Lucio | |
dc.creator | Fejerman, Laura | |
dc.creator | Zabaleta, Jovanny | |
dc.date.accessioned | 2021-03-02T19:10:18Z | |
dc.date.accessioned | 2022-09-27T12:40:40Z | |
dc.date.available | 2021-03-02T19:10:18Z | |
dc.date.available | 2022-09-27T12:40:40Z | |
dc.date.created | 2021-03-02T19:10:18Z | |
dc.date.issued | 2017-08-17 | |
dc.identifier | https://doi.org/10.1371/journal.pone.0183179 | |
dc.identifier | https://repositorio.fucsalud.edu.co/handle/001/1350 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3596444 | |
dc.description.abstract | Background
Hispanic/Latino populations are a genetically admixed and heterogeneous group, with variable fractions of European, Indigenous American and African ancestries. The molecular profile of breast cancer has been widely described in non-Hispanic Whites but equivalent knowledge is lacking in Hispanic/Latinas. We have previously reported that the most prevalent breast cancer intrinsic subtype in Colombian women was Luminal B as defined by St. Gallen 2013 criteria. In this study we explored ancestry-associated differences in molecular profiles of Luminal B tumors among these highly admixed women.
Methods
We performed whole-transcriptome RNA-seq analysis in 42 Luminal tumors (21 Luminal A and 21 Luminal B) from Colombian women. Genetic ancestry was estimated from a panel of 80 ancestry-informative markers (AIM). We categorized patients according to Luminal subtype and to the proportion of European and Indigenous American ancestry and performed differential expression analysis comparing Luminal B against Luminal A tumors according to the assigned ancestry groups.
Results
We found 5 genes potentially modulated by genetic ancestry: ERBB2 (log2FC = 2.367, padj<0.01), GRB7 (log2FC = 2.327, padj<0.01), GSDMB (log2FC = 1.723, padj<0.01, MIEN1 (log2FC = 2.195, padj<0.01 and ONECUT2 (log2FC = 2.204, padj<0.01). In the replication set we found a statistical significant association between ERBB2 expression with Indigenous American ancestry (p = 0.02, B = 3.11). This association was not biased by the distribution of HER2+ tumors among the groups analyzed.
Conclusions
Our results suggest that genetic ancestry in Hispanic/Latina women might modify ERBB2 gene expression in Luminal tumors. Further analyses are needed to confirm these findings and explore their prognostic value. | |
dc.language | eng | |
dc.publisher | San Francisco, California, EE.UU | |
dc.relation | PLos ONE. Vol. 12 Núm. 1 (2017) | |
dc.relation | 21 | |
dc.relation | 8 | |
dc.relation | 1 | |
dc.relation | 12 | |
dc.relation | PLoS ONE | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) | |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | |
dc.rights | http://purl.org/coar/access_right/c_abf2 | |
dc.source | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183179#abstract0 | |
dc.title | Ancestry as a potential modifier of gene expression in breast tumors from Colombian women | |
dc.type | Artículo de revista | |