Síntesis y caracterización de complejos de coordinación con centro metálico de Cu(II) y ligandos derivados de 3,5-dimetilpirazol y ácido 3,5-dinitrobenzóico

dc.contributorHurtado Belalcazar, John Jady
dc.contributorFlores, Areli
dc.contributorMacias Lopez, Mario Alberto
dc.contributorGrupo de investigación en Química Inorgánica, Catálisis y Bioinorgánica
dc.creatorAgudelo Sosa, Elkin Sleider
dc.date.accessioned2022-08-03T18:49:24Z
dc.date.available2022-08-03T18:49:24Z
dc.date.created2022-08-03T18:49:24Z
dc.date.issued2022-07-25
dc.identifierhttp://hdl.handle.net/1992/59547
dc.identifierinstname:Universidad de los Andes
dc.identifierreponame:Repositorio Institucional Séneca
dc.identifierrepourl:https://repositorio.uniandes.edu.co/
dc.description.abstractDurante el paso del tiempo, la automedicación y un incorrecto tratamiento en los residuos de medicamentos, entre otras causas, han llevado a un incremento exponencial en la resistencia de ciertas cepas de microorganismos hacia los medicamentos antimicrobianos tradicionales. Se ha demostrado que múltiples derivados de pirazoles tienen un efecto inhibitorio considerable contra diversas cepas. En muchos casos, el acoplamiento de centros metálicos mejora esta actividad, la química y la biología del cobre ha sido investigada ampliamente demostrando que es un centro metálico apropiado para el uso en complejos con ligandos que contienen heteroátomos de nitrógeno. Adicionalmente, los coligandos de ácido 3,5-dinitrobenzóico tienen propiedades antimicrobianas, por lo que su uso podría significar un aumento en la actividad de los complejos. Con esto en mente, se realizó la síntesis de 5 ligandos derivados de 3,5-dimetilpirazol (L2-L6) y seis complejos de coordinación (1-6), los ligandos y complejos se caracterizaron mediante técnicas analíticas y espectroscópicas para confirmar su formación. Se realizaron estudios en disolución y en estado sólido que pueden dar un indicio sobre su posible aplicación biológica. Se realizó la correcta síntesis y caracterización de ligandos y complejos derivados de 3,5-dimetrilpirazol y ácido dinitrobenzoico y se observó que los complejos formados presentan buena solubilidad en DMSO, alta estabilidad térmica, estabilidad al aire y en disolución. Este resultado es importante resaltarlo considerando que pueden presentar actividad antimicrobiana.
dc.description.abstractOver time, self-medication and incorrect treatment of drug residues, among other causes, have led to an exponential increase in the resistance of certain strains of microorganisms to traditional antimicrobial drugs. Several pyrazole derivatives have been shown to have significant inhibitory effects against a variety of strains. In many cases, the blocking of metal centers improves this activity. The chemistry and biology of copper have been extensively investigated, showing that it is an appropriate metal center for use in complexes with ligands containing nitrogen heteroatoms. In addition, the 3,5-dinitrobenzoic acid coligands have antimicrobial properties, so their use could mean an increase in the activity of the complexes. With this in mind, the synthesis of 5 ligands derived from 3,5-dimethylpyrazole (L2-L6) and six coordination complexes (1-6) was carried out. The ligands and complexes were characterized by analytical and spectroscopic techniques to confirm their formation. Studies were carried out in solution and in solid states that may give an indication of its possible biological application. The correct synthesis and characterization of good ligands and complexes derived from 3,5-dimethylpyrazole and dinitrobenzoic acid was carried out, and it was shown that the complexes formed present solubility in DMSO, high thermal stability, and stability in air and in solution. This result is important to highlight considering that they can present antimicrobial activity.
dc.languagespa
dc.publisherUniversidad de los Andes
dc.publisherMaestría en Química
dc.publisherFacultad de Ciencias
dc.publisherDepartamento de Química
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dc.titleSíntesis y caracterización de complejos de coordinación con centro metálico de Cu(II) y ligandos derivados de 3,5-dimetilpirazol y ácido 3,5-dinitrobenzóico
dc.typeTrabajo de grado - Maestría


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