Design and synthesis of chemosensors based on 7-ferrocenylpyrazolo[1,5-a]pyrimidines for the detection of H+ and CN-

dc.contributorPortilla Salinas, Jaime Antonio
dc.contributorTigreros Ortíz, Alexis
dc.contributorGamba Sánchez, Diego Alexander
dc.contributorChaur Valencia, Manuel Noe
dc.contributorGrupo de Investigación en Compuestos Bio-orgánicos (GICOBIORG)
dc.creatorPeña Bernal, Carlos Arturo
dc.date.accessioned2022-03-10T19:58:08Z
dc.date.available2022-03-10T19:58:08Z
dc.date.created2022-03-10T19:58:08Z
dc.date.issued2021-12
dc.identifierhttp://hdl.handle.net/1992/56303
dc.identifierinstname:Universidad de los Andes
dc.identifierreponame:Repositorio Institucional Séneca
dc.identifierrepourl:https://repositorio.uniandes.edu.co/
dc.description.abstractThis work investigates the rational design of novel chemosensors based on hybrid inorganic/organic structures for detecting H+ and CN-. The synthesis of chemosensors that integrate ferrocene and pyrazolo[1,5-a]pyrimidine molecules is due to the D-A behavior this hybrid system exhibits. A solvatochromic study of 7-ferrocenyl-2-methylpyrazolo[1,5-a]pyrimidine, along with a multiparametric analysis from Catalán's coefficients, is made to understand better how the probe molecule interacts with different solvents in the determination and quantification of H+, with calculated LoD of 0.63 µmol L-1. The integration of an indolium moiety was used for the colorimetric sensing of CN-. The chemosensor showed an intense red coloration losing upon the nucleophilic addition of CN- to the chemosensor molecule with calculated LoD of 0.11 µmol L-1, well below the WHO requirements (1.9 µmol L-1).
dc.languageeng
dc.publisherUniversidad de los Andes
dc.publisherMaestría en Química
dc.publisherFacultad de Ciencias
dc.publisherDepartamento de Química
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dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.titleDesign and synthesis of chemosensors based on 7-ferrocenylpyrazolo[1,5-a]pyrimidines for the detection of H+ and CN-
dc.typeTrabajo de grado - Maestría


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