| dc.description.abstract | The coronavirus disease 2019 (COVID-19) has been spreading worldwide. Severe cases quickly
progressed with unfavorable outcomes.We aim to investigate the clinical features of COVID-19 and
identify the risk factors associated with its progression. Data of confrmed SARS-CoV-2-infected
patients and healthy participants were collected.Thirty-seven healthy people and 79 confrmed
patients, which include 48 severe patients and 31 mild patients, were recruited. COVID-19 patients
presented with dysregulated immune response (decreasedT, B, and NK cells and increased
infammatory cytokines).Also, they were found to have increased levels of white blood cell, neutrophil
count, and D-dimer in severe cases. Moreover, lymphocyte, CD4+T cell, CD8+T cell, NK cell, and B cell
counts were lower in the severe group. Multivariate logistic regression analysis showed that CD4+
cell
count, neutrophil-to-lymphocyte ratio (NLR) and D-dimer were risk factors for severe cases. Both CT
score and clinical pulmonary infection score (CPIS) were associated with disease severity.The receiver
operating characteristic (ROC) curve analysis has shown that all these parameters and scores had
quite a high predictive value. Immune dysfunction plays critical roles in disease progression. Early and
constant surveillance of complete blood cell count,T lymphocyte subsets, coagulation function, CT
scan and CPIS was recommended for early screening of severe cases. | |
