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        • Universidad Jorge Tadeo Lozano (Colombia)
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        Cytokine storm and immunomodulatory therapy in COVID-19: Role of chloroquine and anti-IL-6 monoclonal antibodies

        Registro en:
        0924-8579
        https://doi.org/10.1016/j.ijantimicag.2020.105982
        http://hdl.handle.net/20.500.12010/10647
        https://doi.org/10.1016/j.ijantimicag.2020.105982
        http://repositorioslatinoamericanos.uchile.cl/handle/2250/3506596
        Autor
        Zhao, Ming
        Institución
        • Universidad Jorge Tadeo Lozano (Colombia)
        Resumen
        Severe acute respiratory syndrome coronavirus-2, the causative agent of coronavirus disease 2019 (COVID-19), was declared a pandemic by the World Health Organization on 11th March 2020 and is a major global health concern. How to treat patients with COVID19 effectively is a common question for physicians worldwide. According to recent statistical data released by the Chinese Government, approximately 19% of cases of COVID-19 are severe or critical. Huang et al. reported the clinical features and cytokine profile of critically ill patients with COVID-19 in Wuhan, China, and suggested that a cytokine storm (i.e. higher concentrations of granulocyte-colony stimulating factor, interferon gamma-induced protein 10, monocyte chemoattractant protein 1, macrophage inflammatory protein 1α and tumour necrosis factor α) could be associated with the severity of disease [1]. Another study from China reported that increased expression of interleukin (IL)-2R and IL-6 in serum appears to predict the severity and prognosis of patients with COVID-19 [2]. Additionally, pathological examination of a biopsy sample from a patient who died from COVID19 revealed interstitial mononuclear inflammatory infiltrates in both lungs, dominated by lymphocytes [3]. Furthermore, peripheral blood flow cytometric analysis showed that overactivation of T cells accounted, in part, for the severe immune injury in this patient [3]. Thus, cytokine storms should not be neglected in the treatment of COVID-19.
        Materias
        COVID-19
        Cytokine storm
        Chloroquine
        Hydroxychloroquine
        Tocilizumab

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        Red de Repositorios Latinoamericanos
        + de 8.000.000 publicaciones disponibles
        500 instituciones participantes
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Ingreso Administradores
        Colecciones destacadas
        • Tesis latinoamericanas
        • Tesis argentinas
        • Tesis chilenas
        • Tesis peruanas
        Nuevas incorporaciones
        • Argentina
        • Brasil
        • Colombia
        • México
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018