dc.creator | Hastie, Claire E. | |
dc.creator | Mackay, Daniel F. | |
dc.creator | Ho, Frederick | |
dc.creator | Celis-Morales, Carlos A. | |
dc.creator | Vittal Katikireddi, Srinivasa | |
dc.creator | Niedzwiedz, Claire L. | |
dc.creator | Jani, Bhautesh D. | |
dc.creator | Welsh, Paul | |
dc.creator | Mair, Frances S. | |
dc.creator | Gray, Stuart R. | |
dc.creator | O’Donnell, Catherine A. | |
dc.creator | Gill, Jason MR. | |
dc.creator | Sattar, Naveed | |
dc.creator | Pell, Jill P. | |
dc.date.accessioned | 2020-07-10T17:12:32Z | |
dc.date.accessioned | 2022-09-23T18:40:16Z | |
dc.date.available | 2020-07-10T17:12:32Z | |
dc.date.available | 2022-09-23T18:40:16Z | |
dc.date.created | 2020-07-10T17:12:32Z | |
dc.identifier | 1871-4021 | |
dc.identifier | https://doi.org/10.1016/j.dsx.2020.04.050 | |
dc.identifier | http://hdl.handle.net/20.500.12010/10401 | |
dc.identifier | https://doi.org/10.1016/j.dsx.2020.04.050 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3505256 | |
dc.description.abstract | Background and aims: COVID-19 and low levels of vitamin D appear to disproportionately affect black
and minority ethnic individuals. We aimed to establish whether blood 25-hydroxyvitamin D (25(OH)D)
concentration was associated with COVID-19 risk, and whether it explained the higher incidence of
COVID-19 in black and South Asian people.
Methods: UK Biobank recruited 502,624 participants aged 37e73 years between 2006 and 2010. Baseline
exposure data, including 25(OH)D concentration and ethnicity, were linked to COVID-19 test results.
Univariable and multivariable logistic regression analyses were performed for the association between
25(OH)D and confirmed COVID-19, and the association between ethnicity and both 25(OH)D and COVID19.
Results: Complete data were available for 348,598 UK Biobank participants. Of these, 449 had confirmed
COVID-19 infection. Vitamin D was associated with COVID-19 infection univariably (OR ¼ 0.99; 95% CI
0.99e0.999; p ¼ 0.013), but not after adjustment for confounders (OR ¼ 1.00; 95% CI ¼ 0.998e1.01;
p ¼ 0.208). Ethnicity was associated with COVID-19 infection univariably (blacks versus whites
OR ¼ 5.32, 95% CI ¼ 3.68e7.70, p-value<0.001; South Asians versus whites OR ¼ 2.65, 95% CI ¼ 1.65
e4.25, p-value<0.001). Adjustment for 25(OH)D concentration made little difference to the magnitude of
the association.
Conclusions: Our findings do not support a potential link between vitamin D concentrations and risk of
COVID-19 infection, nor that vitamin D concentration may explain ethnic differences in COVID-19
infection. | |
dc.publisher | Science Direct | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.source | reponame:Expeditio Repositorio Institucional UJTL | |
dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | |
dc.subject | COVID-19 | |
dc.subject | Vitamin D | |
dc.subject | Ethnicity | |
dc.title | Vitamin D concentrations and COVID-19 infection in UK Biobank | |