Hyperinflammation and the utility of immunomodulatory medications in chil‐ dren with COVID-19
Autor
Tanner, Tamara
Wahezi, Dawn M.
Institución
Resumen
The rapid spread of SARS-CoV-2 infection globally coupled with the relatively high case-fatality rate has
led to immediate need for therapeutic intervention to prevent and treat COVID-19 disease. There is
accumulating evidence that morbidity and mortality in COVID-19 may be exacerbated by a dysregulated
host immune response resulting in significant hyperinflammation and cytokine release. The aim of this
review is to describe the basis for the immune dysregulation caused by SARS-CoV-2 infection and to
examine current investigations into immunomodulatory therapies aimed at targeting the excessive host
immune response.