dc.creatorConsiglio, Camila Rosat
dc.creatorCotugno, Nicola
dc.creatorSardh, Fabian
dc.creatorPou, Christian
dc.creatorAmodio, Donato
dc.creatorRodriguez, Lucie
dc.creatorTan, Ziyang
dc.creatorZicari, Sonia
dc.creatorRuggiero, Alessandra
dc.creatorPascucci, Giuseppe Rubens
dc.creatorSantilli, Veronica
dc.creatorCampbell, Tessa
dc.creatorBryceson, Yenan
dc.creatorEriksson, Daniel
dc.creatorWang, Jun
dc.creatorMarchesi, Alessandra
dc.creatorLakshmikanth, Tadepally
dc.creatorCampana, Andrea
dc.creatorVillani, Alberto
dc.creatorRossi, Paolo
dc.date.accessioned2020-09-30T16:06:52Z
dc.date.accessioned2022-09-23T18:32:17Z
dc.date.available2020-09-30T16:06:52Z
dc.date.available2022-09-23T18:32:17Z
dc.date.created2020-09-30T16:06:52Z
dc.identifier1097-4172
dc.identifierhttps://doi.org/10.1016/j.cell.2020.09.016
dc.identifierhttp://hdl.handle.net/20.500.12010/14022
dc.identifierhttps://doi.org/10.1016/j.cell.2020.09.016
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3502758
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often asymptomatic in children. A complication is the rare multisystem inflammatory syndrome in children (MISC) associated with COVID-19, presenting 4–6 weeks after infection as high fever, organ dysfunction, and strongly elevated markers of inflammation. The pathogenesis is unclear but has overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology. We apply systems-level analyses of blood immune cells, cytokines, and autoantibodies in healthy children, children with Kawasaki disease enrolled prior to COVID-19, children infected with SARS-CoV-2, and children presenting with MIS-C. We find that the inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage. Finally, autoantibody profiling suggests multiple autoantibodies that could be involved in the pathogenesis of MIS-C.
dc.languageeng
dc.publisherCell
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAbierto (Texto Completo)
dc.sourcereponame:Expeditio Repositorio Institucional UJTL
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozano
dc.subjectImmunology
dc.subjectInflammatory Syndrome in Children
dc.subjectCOVID-19
dc.titleThe Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19


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