dc.creator | Consiglio, Camila Rosat | |
dc.creator | Cotugno, Nicola | |
dc.creator | Sardh, Fabian | |
dc.creator | Pou, Christian | |
dc.creator | Amodio, Donato | |
dc.creator | Rodriguez, Lucie | |
dc.creator | Tan, Ziyang | |
dc.creator | Zicari, Sonia | |
dc.creator | Ruggiero, Alessandra | |
dc.creator | Pascucci, Giuseppe Rubens | |
dc.creator | Santilli, Veronica | |
dc.creator | Campbell, Tessa | |
dc.creator | Bryceson, Yenan | |
dc.creator | Eriksson, Daniel | |
dc.creator | Wang, Jun | |
dc.creator | Marchesi, Alessandra | |
dc.creator | Lakshmikanth, Tadepally | |
dc.creator | Campana, Andrea | |
dc.creator | Villani, Alberto | |
dc.creator | Rossi, Paolo | |
dc.date.accessioned | 2020-09-30T16:06:52Z | |
dc.date.accessioned | 2022-09-23T18:32:17Z | |
dc.date.available | 2020-09-30T16:06:52Z | |
dc.date.available | 2022-09-23T18:32:17Z | |
dc.date.created | 2020-09-30T16:06:52Z | |
dc.identifier | 1097-4172 | |
dc.identifier | https://doi.org/10.1016/j.cell.2020.09.016 | |
dc.identifier | http://hdl.handle.net/20.500.12010/14022 | |
dc.identifier | https://doi.org/10.1016/j.cell.2020.09.016 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3502758 | |
dc.description.abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often
asymptomatic in children. A complication is the rare multisystem inflammatory syndrome in children (MISC) associated with COVID-19, presenting 4–6 weeks after infection as high fever, organ dysfunction, and
strongly elevated markers of inflammation. The pathogenesis is unclear but has overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology. We apply systems-level analyses of
blood immune cells, cytokines, and autoantibodies in healthy children, children with Kawasaki disease
enrolled prior to COVID-19, children infected with SARS-CoV-2, and children presenting with MIS-C. We
find that the inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19,
shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage. Finally, autoantibody profiling
suggests multiple autoantibodies that could be involved in the pathogenesis of MIS-C. | |
dc.language | eng | |
dc.publisher | Cell | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Abierto (Texto Completo) | |
dc.source | reponame:Expeditio Repositorio Institucional UJTL | |
dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | |
dc.subject | Immunology | |
dc.subject | Inflammatory Syndrome in Children | |
dc.subject | COVID-19 | |
dc.title | The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19 | |