COVID-19 and multisystem inflammatory syndrome in children and adolescents
Autor
Jiang, Li
Tang, Kun
Levin, Mike
Irfan, Omar
Morris, Shaun K
Wilson, Karen
Klein, Jonathan D
Bhutta, Zulfiqar A
Institución
Resumen
As severe acute respiratory syndrome coronavirus 2 continues to spread worldwide, there have been increasing
reports from Europe, North America, Asia, and Latin America describing children and adolescents with
COVID-19-associated multisystem inflammatory conditions. However, the association between multisystem
inflammatory syndrome in children and COVID-19 is still unknown. We review the epidemiology, causes, clinical
features, and current treatment protocols for multisystem inflammatory syndrome in children and adolescents
associated with COVID-19. We also discuss the possible underlying pathophysiological mechanisms for COVID-19-
induced inflammatory processes, which can lead to organ damage in paediatric patients who are severely ill. These
insights provide evidence for the need to develop a clear case definition and treatment protocol for this new condition
and also shed light on future therapeutic interventions and the potential for vaccine development.