Essential functional molecules associated with SARS-CoV-2 infection: Poten‐ tial therapeutic targets for COVID-19
Author
Rajarshi, Keshav
Khan, Rajni
Singh, Mrityunjay K
Ranjan, Tushar
Ray, Sandipan
Ray, Shashikant
Institutions
Abstract
The whole world is still suffering substantially from the coronavirus disease 2019 (COVID19) outbreak. Several protein-based molecules that are associated with the Severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), which are essential for its functionality,
survival, and pathogenesis have been identified and are considered as potential therapeutic
targets. These protein-based molecules are either structural/non-structural components of
SARS-CoV-2 or host factors, which play a crucial role in this infection. Developing drug
molecules against these essential functional molecules to hinder their regular functioning and
associated physiological pathways could be promising for successful clinical management of
this novel coronavirus infection. The review aims to highlight the functional molecules that
play crucial roles in SARS-CoV-2 pathogenesis. We have emphasized how these potential
druggable targets could be beneficial in tackling the COVID-19 crisis.