Immunology of COVID-19: Current State of the Science
Autor
Vabret, Nicolas
Britton, Graham J.
Gruber, Conor
Hegde, Samarth
Kim, Joel
Kuksin, Maria
Levantovsky, Rachel
Malle, Louise
Moreira, Alvaro
Park, Matthew D.
Pia, Luisanna
Risson, Emma
Saffern, Miriam
Salome, Berengere
Esai Selvan, Myvizhi
Spindler, Matthew P.
Tan, Jessica
Heide, Verena van der
Gregory, Jill K.
Alexandropoulos, Konstantina
Bhardwaj, Nina
Brown, Brian D.
Greenbaum, Benjamin
Gumus, Zeynep H.
Homann, Dirk
Horowitz, Amir
Kamphorst, Alice O.
Curotto de Lafaille, Maria A.
Mehandru, Saurabh
Merad, Miriam
Samstein, Robert M.
Institución
Resumen
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the
scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review,
we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARSCoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We
also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.