dc.creator | Rodriguez-Morales, Alfonso J. | |
dc.creator | Cardona-Ospina, Jaime A. | |
dc.creator | Gutiérrez-Ocampo, Estefanía | |
dc.creator | Villamizar-Peña, Rhuvi | |
dc.creator | Holguin-Rivera, Yeimer | |
dc.creator | Escalera-Antezana, Juan Pablo | |
dc.creator | Alvarado-Arnez, Lucia Elena | |
dc.creator | Bonilla-Aldana, D. Katterine | |
dc.creator | Franco-Paredes, Carlos | |
dc.creator | Henao-Martinez, Andrés F. | |
dc.creator | Paniz-Mondolf, Alberto | |
dc.creator | Lagos-Grisales, Guillermo J. | |
dc.creator | Ramírez-Vallejo, Eduardo | |
dc.creator | Suárez, Jose A. | |
dc.creator | Zambrano, Lysien I. | |
dc.creator | Villamil-Gómez, Wilmer E. | |
dc.creator | Balbin-Ramon, Graciela J. | |
dc.creator | Rabaan, Ali A. | |
dc.creator | Harapan, Harapan | |
dc.creator | Dhama, Kuldeep | |
dc.creator | Nishiura, Hiroshi | |
dc.creator | Kataoka, Hiromitsu | |
dc.creator | Ahmad, Tauseef | |
dc.creator | Sah, Ranjit | |
dc.date.accessioned | 2020-07-16T20:40:38Z | |
dc.date.accessioned | 2022-09-23T18:08:09Z | |
dc.date.available | 2020-07-16T20:40:38Z | |
dc.date.available | 2022-09-23T18:08:09Z | |
dc.date.created | 2020-07-16T20:40:38Z | |
dc.identifier | 1477-8939 | |
dc.identifier | https://doi.org/10.1016/j.tmaid.2020.101623 | |
dc.identifier | http://hdl.handle.net/20.500.12010/10701 | |
dc.identifier | https://doi.org/10.1016/j.tmaid.2020.101623 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3495992 | |
dc.description.abstract | Introduction: An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 in China leading to
a Public Health Emergency of International Concern (PHEIC). Clinical, laboratory, and imaging features have
been partially characterized in some observational studies. No systematic reviews on COVID-19 have been
published to date.
Methods: We performed a systematic literature review with meta-analysis, using three databases to assess
clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and
also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis
to calculate pooled prevalences and 95% confidence intervals (95%CI).
Results: 660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were
selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally,
39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI
84.5–92.9%), cough (57.6%, 95%CI 40.8–74.4%) and dyspnea (45.6%, 95%CI 10.9–80.4%) were the most
prevalent manifestations. Among the patients, 20.3% (95%CI 10.0–30.6%) required intensive care unit (ICU),
32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7–51.8), 6.2% (95%CI 3.1–9.3)
with shock. Some 13.9% (95%CI 6.2–21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR).
Conclusion: COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities.
ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was
associated with a CFR of > 13%. As this virus spreads globally, countries need to urgently prepare human
resources, infrastructure and facilities to treat severe COVID-19. | |
dc.publisher | Science Direct | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.source | reponame:Expeditio Repositorio Institucional UJTL | |
dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | |
dc.subject | Coronavirus disease 2019 | |
dc.subject | SARS-CoV-2 | |
dc.subject | Clinical features | |
dc.subject | Laboratory | |
dc.subject | Outcomes | |
dc.subject | Epidemic | |
dc.title | Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis | |