Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity
Autor
Wang, Lin
Wang, Ling
Zhuang, Hui
Institución
Resumen
Using high-throughput pseudovirus assay in conjunction with
neutralizing antibodies, Wang et al. investigated 80 natural
variants and 26 glycosylation-spike (S) mutants of SARS-CoV-2 in
terms of infectivity and antigenicity.1 They identified several
mutations that can critically affect the virus infectivity and
reactivity to neutralizing antibodies (Fig. 1). This study provides
abundant and comprehensive data that will help us better
understand the impact of mutations in S protein, and may
contribute to future design of potent vaccine candidate and
monoclonal antibodies (mAbs).