dc.creatorAta, Fateen
dc.creatorBilal, Ammara Bint I
dc.creatorJaved, Saad
dc.creatorChaudhry, Hammad Shabir
dc.creatorSharma, Rohit
dc.creatorMalik, Rubab Fatima
dc.creatorChoudry, Hassan
dc.creatorKartha, Anand Bhaskaran
dc.date.accessioned2020-11-10T15:36:33Z
dc.date.accessioned2022-09-23T18:02:28Z
dc.date.available2020-11-10T15:36:33Z
dc.date.available2022-09-23T18:02:28Z
dc.date.created2020-11-10T15:36:33Z
dc.identifier2049-0801
dc.identifierhttps://doi.org/10.1016/j.amsu.2020.11.010
dc.identifierhttp://hdl.handle.net/20.500.12010/15592
dc.identifierhttps://doi.org/10.1016/j.amsu.2020.11.010
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3493731
dc.description.abstractIntroduction: Vitamin B12 (VitB12) deficiency rarely manifests with visual symptoms. Optic nerve damage in VitB12 deficiency is thought to be via degeneration. However, optic neuritis, though infrequent, has been reported secondary to VitB12 deficiency. Material and methods: We conducted a systematic review of all the reported cases of VitB12 deficiency with optic nerve involvement in Pubmed, Cochrane, and Google Scholar any date up to September 6, 2020. We have discussed the findings and compiled the available information on ophthalmological manifestations of VitB12 deficiency. We aim to provide a unified knowledge about the evidence related to types of optic neuropathies reported to date secondary to VitB12 deficiency. We also present a case of bilateral optic neuritis secondary to VitB12 deficiency. Presentation of case: We present a 29-year-old previously healthy male with progressive, painful, bilateral, but asymmetric visual deterioration for forty-five days. A detailed history, examination, and laboratory workup were carried out. He was diagnosed as having optic neuritis secondary to VitB12 deficiency. He showed partial improvement with the replacement of VitB12. Conclusion: We suggest promptly identifying and replacing VitB12 in patients with optic neuritis with proven VitB12 deficiency to prevent permanent damage to the optic nerve. Patients with VitB12 deficiency should have a baseline fundoscopic exam to rule out subclinical optic nerve damage. Moreover, patients who present with visual disturbances should be screened for VitB12 deficiency, especially the vegan population.
dc.languageeng
dc.publisherAnnals of Medicine and Surgery
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAbierto (Texto Completo)
dc.sourcereponame:Expeditio Repositorio Institucional UJTL
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozano
dc.subjectVitamin B – 12 deficiency
dc.subjectCyanocobalamin deficiency
dc.subjectOptic neuritis
dc.subjectOptic nerve
dc.subjectOptic neuropathy
dc.subjectOphthalmological manifestations
dc.subjectVisual symptoms
dc.titleOptic neuropathy as a presenting feature of vitamin B-12 deficiency: A systematic review of literature and a case report


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