journal article
Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring
Fecha
2020-09-25Registro en:
Garzón V., Bustos R.H., Pinacho D. (2020). Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring. Journal of Personalized Medicine. 10, 147. p.p. 1-34. doi.org/10.3390/jpm10040147. ISSN 2075-4426
2075-4426
10.3390/jpm10040147
Institución
Resumen
Due to the high bacterial resistance to antibiotics (AB), it has become necessary to adjust
the dose aimed at personalized medicine by means of therapeutic drug monitoring (TDM). TDM is a
fundamental tool for measuring the concentration of drugs that have a limited or highly toxic dose in
different body fluids, such as blood, plasma, serum, and urine, among others. Using different techniques
that allow for the pharmacokinetic (PK) and pharmacodynamic (PD) analysis of the drug, TDM can
reduce the risks inherent in treatment. Among these techniques, nanotechnology focused on biosensors,
which are relevant due to their versatility, sensitivity, specificity, and low cost. They provide results in
real time, using an element for biological recognition coupled to a signal transducer. This review describes
recent advances in the quantification of AB using biosensors with a focus on TDM as a fundamental
aspect of personalized medicine.