A computational model for the modulation of the prepulseinhibition of the acoustic startle reflex

dc.creatorRamirez-Moreno, David Fernando
dc.creatorSejnowski, Terrence Joseph
dc.date.accessioned2019-11-29T14:51:17Z
dc.date.available2019-11-29T14:51:17Z
dc.date.created2019-11-29T14:51:17Z
dc.date.issued2012
dc.identifierhttp://red.uao.edu.co//handle/10614/11619
dc.identifier10.1007/s00422-012-0485-7
dc.description.abstractThe acoustic startle reflex (ASR), a defensiveresponse, is a contraction of the skeletal and facial musclesin response to an abrupt, intense (>80 db) auditory stimu-lus, which has been extensively studied in rats and humans.Prepulse inhibition (PPI) of ASR is the normal suppressionof the startle reflex when an intense stimulus is preceded bya weak non-starting pre-stimulus. PPI, a measure of sensorymotor gating, is impaired in various neuropsychiatric disor-ders, including schizophrenia, and is modulated by cogni-tive and emotional contexts such as fear and attention. Wehave modeled the fear modulation of PPI of ASR based onits anatomical substrates and taking into account data frombehaving rats and humans. The model replicates the principalfeatures of both phenomena and predicts underlying neuralmechanisms. In addition, the model yields testable predictions
dc.languageeng
dc.publisherSpringer
dc.relation176
dc.relation169
dc.relation106
dc.relationRamirez-Moreno, D.F., Sejnowski, T.J. A computational model for the modulation of the prepulse inhibition of the acoustic startle reflex. Biol Cybern 106, 169–176 (2012). https://doi.org/10.1007/s00422-012-0485-7
dc.relationBiological cybernetics
dc.relationBast T et al (2001) Hyperactivity, decreased startle reactivity, and dis- rupted prepulse inhibition following disinhibition of the rat ventral hippocampus by the GABAA receptor antagonist picrotoxin. Psy- chopharmacology 156(2–3):225–233 Braff DL et al (2001) Human studies of prepulse inhibition of star- tle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berl) 156:234–258 Davis M (2006) Neural systems involved in fear and anxiety measured with fear—potentiated startle. Am Psychol 61:741–756 Depoortere R et al (1997) Potentiation of prepulse inhibition of the star- tle reflex in rats: pharmacological evaluation of the procedure as a model for detecting antipsychotic activity. Psycopharmacology (Berl) 132(4):366–374 Fendt M et al (2001) Brain stem circuits mediating prepulse inhibition of the startle reflex. Psychopharmacology 156:216–224 Geyer MA et al (2001) Pharmacological studies of prepulse inhibition models of sensorimotor-gating deficits in schizophrenia: a decade in review. Psychopharmacology 156:117–154 Grillon C (1998) Effect of darkness on acoustic startle in Vietnam vet- erans with PTSD. Am J Psychiatry 155:812–817 Grillon C et al (1997) Darkness facilitates the acoustic startle reflex in humans. Biol Psychiatry 42(6):453–460 Heekeren K et al (2004) Attentional modulation of prepulse inhibition: a new startle paradigm. Neuropsychobiology 49:88–93 Hoffman HS, Ison JR (1980) Reflex modification in the domain of star- tle: I. Some empirical findings and their implications for how the nervous system processes sensory input. Psychol Rev 87:175–189 Hoffman HS, Searle JL (1965) Acoustic variables in the modification of startle reaction in the rat. J Comp Physiol Psychol 60(1):53–58 Ishii D et al (2010) Enhancement of acoustic prepulse inhibition by contextual fear conditioning in mice is maintained even after con- textual fear extinction. Prog Neuropsychopharmacol Biol Psychi- atry 34:183–188 Iversen S et al (2000) Emotional states and feelings. In: Kandel E, Sch- wartz JH, Jessell TM (eds) Principles of neuroscience, 4th edn. McGraw-Hill, New York, pp 982–998 Koch M (1999) The neurobiology of startle. Prog Neurobiol 59:107– 128 Koch M et al (1992) Loss of the acoustic startle response following neurotoxic lesions of the caudal pontine reticular formation: pos- sible role of giant neurons. Neuroscience 49:617–625 Koch M et al (1997) The acoustic startle response in rats—circuits mediating evocation, inhibition and potentiation. Behav Brain Res 89:35–49 Lang PJ et al (1990) Emotion, attention, and the startle reflex. Psychol Rev 97:377–395 Lang PJ, Davis M, Ohman A (2000) Fear and anxiety: animal models and human cognitive psychophysiology. J Affect Disord 61:137– 159 Lapicque L (1907) Recherches quantitatives sur l’excitation électrique des nerfs traitée comme une polarisation. J Physiol Pathol Gen 9:620–635 Lee Y et al (1996) A primary acoustic startle reflex pathway: obligatory role of cochlear root neurons and the nucleus reticularis pontis caudalis. J Neurosci 16(11):3775–3789 Leitner DS et al (1985) Role of the inferior colliculus in the inhibition of acoustic startle in the rat. Physiol Behav 34:65–70 Leumann L et al (2001) A neural network approach to the acoustic star- tle reflex and prepulse inhibition. Brain Res Bull 56(2):101–110 Li L et al (1998) Prepulse inhibition following lesions of the inferior colliculus: prepulse intensity functions. Physiol Behav 65:133– 139 Li L et al (2009) Top-down modulations of prepulse inhibition of the startle reflex in humans and rats. Neurosci Behav Rev 33:1157– 1167 Naka KI, Rushton WAH (1966) S-potentials from luminosity units in the retina of fish (Cyprinidae). J Physiol 185:587–599 Plappert C, Pilz P, Schnitzler H (2004) Factors governing prepulse inhi- bition and prepulse facilitation of the acoustic startle response in mice. Behav Brain Res 152:403–412 Schmajuk NA et al (2006) Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis. Behav Brain Res 170:182–196 Shepherd GM (2004) Introduction to synaptic circuits. In: Shepherd GM (ed) The synaptic organization of the brain, 5th edn. Oxford University Press, Oxford Swerdlow NR, Geyer MA (1993) Prepulse inhibition of acoustic star- tle in rats after lesions of the pedunculopontine tegmental nucleus. Behav Neurosci 107:104–117 Swerdlow NR, Caine SB, Braff DL, Geyer MA (1992) The neural sub- strates of sensorimotor gating of the startle reflex: a reviewof recent findings and their implications. Psychopharmacology 6:176–190 Swerdlow NR et al (2001) Neural circuit regulation of prepulse inhibi- tion of startle in the rat: current knowledge and future challenges. Psychopharmacology 156:194–215 Vogt BA (2005) Pain and emotion interactions in subregions of the cingulated gyrus. Nat Rev Neurosci 6:533–544 Wilson C (2004) Basal ganglia. In: Shepherd G (ed) The synaptic orga- nization of the brain, 5th edn. Oxford Press, Oxford, pp 361–415 Winslow JT, Parr LA, Davis M (2002) Acoustic startle, prepulse inhi- bition, and fear-potentiated startle measured in rhesus monkeys. Biol Psychiatry 51:859–866 Yeomans JS et al (2006) Midbrain pathways for prepulse inhibition and startle activation in rats. Neuroscience 142:921–929 Bast T et al (2001) Hyperactivity, decreased startle reactivity, and dis- rupted prepulse inhibition following disinhibition of the rat ventral hippocampus by the GABAA receptor antagonist picrotoxin. Psy- chopharmacology 156(2–3):225–233 Braff DL et al (2001) Human studies of prepulse inhibition of star- tle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berl) 156:234–258 Davis M (2006) Neural systems involved in fear and anxiety measured with fear—potentiated startle. Am Psychol 61:741–756 Depoortere R et al (1997) Potentiation of prepulse inhibition of the star- tle reflex in rats: pharmacological evaluation of the procedure as a model for detecting antipsychotic activity. Psycopharmacology (Berl) 132(4):366–374 Fendt M et al (2001) Brain stem circuits mediating prepulse inhibition of the startle reflex. Psychopharmacology 156:216–224 Geyer MA et al (2001) Pharmacological studies of prepulse inhibition models of sensorimotor-gating deficits in schizophrenia: a decade in review. Psychopharmacology 156:117–154 Grillon C (1998) Effect of darkness on acoustic startle in Vietnam vet- erans with PTSD. Am J Psychiatry 155:812–817 Grillon C et al (1997) Darkness facilitates the acoustic startle reflex in humans. Biol Psychiatry 42(6):453–460 Heekeren K et al (2004) Attentional modulation of prepulse inhibition: a new startle paradigm. Neuropsychobiology 49:88–93 Hoffman HS, Ison JR (1980) Reflex modification in the domain of star- tle: I. Some empirical findings and their implications for how the nervous system processes sensory input. Psychol Rev 87:175–189 Hoffman HS, Searle JL (1965) Acoustic variables in the modification of startle reaction in the rat. J Comp Physiol Psychol 60(1):53–58 Ishii D et al (2010) Enhancement of acoustic prepulse inhibition by contextual fear conditioning in mice is maintained even after con- textual fear extinction. Prog Neuropsychopharmacol Biol Psychi- atry 34:183–188 Iversen S et al (2000) Emotional states and feelings. In: Kandel E, Sch- wartz JH, Jessell TM (eds) Principles of neuroscience, 4th edn. McGraw-Hill, New York, pp 982–998 Koch M (1999) The neurobiology of startle. Prog Neurobiol 59:107– 128 Koch M et al (1992) Loss of the acoustic startle response following neurotoxic lesions of the caudal pontine reticular formation: pos- sible role of giant neurons. Neuroscience 49:617–625 Koch M et al (1997) The acoustic startle response in rats—circuits mediating evocation, inhibition and potentiation. Behav Brain Res 89:35–49 Lang PJ et al (1990) Emotion, attention, and the startle reflex. Psychol Rev 97:377–395 Lang PJ, Davis M, Ohman A (2000) Fear and anxiety: animal models and human cognitive psychophysiology. J Affect Disord 61:137– 159 Lapicque L (1907) Recherches quantitatives sur l’excitation électrique des nerfs traitée comme une polarisation. J Physiol Pathol Gen 9:620–635 Lee Y et al (1996) A primary acoustic startle reflex pathway: obligatory role of cochlear root neurons and the nucleus reticularis pontis caudalis. J Neurosci 16(11):3775–3789 Leitner DS et al (1985) Role of the inferior colliculus in the inhibition of acoustic startle in the rat. Physiol Behav 34:65–70 Leumann L et al (2001) A neural network approach to the acoustic star- tle reflex and prepulse inhibition. Brain Res Bull 56(2):101–110 Li L et al (1998) Prepulse inhibition following lesions of the inferior colliculus: prepulse intensity functions. Physiol Behav 65:133– 139 Li L et al (2009) Top-down modulations of prepulse inhibition of the startle reflex in humans and rats. Neurosci Behav Rev 33:1157– 1167 Naka KI, Rushton WAH (1966) S-potentials from luminosity units in the retina of fish (Cyprinidae). J Physiol 185:587–599 Plappert C, Pilz P, Schnitzler H (2004) Factors governing prepulse inhi- bition and prepulse facilitation of the acoustic startle response in mice. Behav Brain Res 152:403–412 Schmajuk NA et al (2006) Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis. Behav Brain Res 170:182–196 Shepherd GM (2004) Introduction to synaptic circuits. In: Shepherd GM (ed) The synaptic organization of the brain, 5th edn. Oxford University Press, Oxford Swerdlow NR, Geyer MA (1993) Prepulse inhibition of acoustic star- tle in rats after lesions of the pedunculopontine tegmental nucleus. Behav Neurosci 107:104–117 Swerdlow NR, Caine SB, Braff DL, Geyer MA (1992) The neural sub- strates of sensorimotor gating of the startle reflex: a reviewof recent findings and their implications. Psychopharmacology 6:176–190 Swerdlow NR et al (2001) Neural circuit regulation of prepulse inhibi- tion of startle in the rat: current knowledge and future challenges. Psychopharmacology 156:194–215 Vogt BA (2005) Pain and emotion interactions in subregions of the cingulated gyrus. Nat Rev Neurosci 6:533–544 Wilson C (2004) Basal ganglia. In: Shepherd G (ed) The synaptic orga- nization of the brain, 5th edn. Oxford Press, Oxford, pp 361–415 Winslow JT, Parr LA, Davis M (2002) Acoustic startle, prepulse inhi- bition, and fear-potentiated startle measured in rhesus monkeys. Biol Psychiatry 51:859–866 Yeomans JS et al (2006) Midbrain pathways for prepulse inhibition and startle activation in rats. Neuroscience 142:921–929 Bast T et al (2001) Hyperactivity, decreased startle reactivity, and dis-rupted prepulse inhibition following disinhibition of the rat ventralhippocampus by the GABAA receptor antagonist picrotoxin. Psy-chopharmacology 156(2–3):225–233
dc.relationBraff DL et al (2001) Human studies of prepulse inhibition of star-tle: normal subjects, patient groups, and pharmacological studies.Psychopharmacology (Berl) 156:234–258
dc.relationDavis M (2006) Neural systems involved in fear and anxiety measuredwith fear—potentiated startle. Am Psychol 61:741–756
dc.relationDepoortere R et al (1997) Potentiation of prepulse inhibition of the star-tle reflex in rats: pharmacological evaluation of the procedure asa model for detecting antipsychotic activity. Psycopharmacology(Berl) 132(4):366–374
dc.relationFendt M et al (2001) Brain stem circuits mediating prepulse inhibitionof the startle reflex. Psychopharmacology 156:216–224
dc.relationGeyer MA et al (2001) Pharmacological studies of prepulse inhibitionmodels of sensorimotor-gating deficits in schizophrenia: a decadein review. Psychopharmacology 156:117–154
dc.relationGrillon C (1998) Effect of darkness on acoustic startle in Vietnam vet-erans with PTSD. Am J Psychiatry 155:812–817
dc.relationGrillon C et al (1997) Darkness facilitates the acoustic startle reflex inhumans. Biol Psychiatry 42(6):453–460
dc.relationHeekeren K et al (2004) Attentional modulation of prepulse inhibition:a new startle paradigm. Neuropsychobiology 49:88–93
dc.relationHoffman HS, Ison JR (1980) Reflex modification in the domain of star-tle: I. Some empirical findings and their implications for how thenervous system processes sensory input. Psychol Rev 87:175–189
dc.relationHoffman HS, Searle JL (1965) Acoustic variables in the modificationof startle reaction in the rat. J Comp Physiol Psychol 60(1):53–58
dc.relationIshii D et al (2010) Enhancement of acoustic prepulse inhibition bycontextual fear conditioning in mice is maintained even after con-textual fear extinction. Prog Neuropsychopharmacol Biol Psychi-atry 34:183–188
dc.relationIversen S et al (2000) Emotional states and feelings. In: Kandel E, Sch-wartz JH, Jessell TM (eds) Principles of neuroscience, 4th edn.McGraw-Hill, New York, pp 982–998
dc.relationKoch M (1999) The neurobiology of startle. Prog Neurobiol 59:107–128
dc.relationKoch M et al (1992) Loss of the acoustic startle response followingneurotoxic lesions of the caudal pontine reticular formation: pos-sible role of giant neurons. Neuroscience 49:617–625
dc.relationKoch M et al (1997) The acoustic startle response in rats—circuitsmediating evocation, inhibition and potentiation. Behav Brain Res89:35–49
dc.relationLang PJ et al (1990) Emotion, attention, and the startle reflex. PsycholRev 97:377–395
dc.relationLang PJ, Davis M, Ohman A (2000) Fear and anxiety: animal modelsand human cognitive psychophysiology. J Affect Disord 61:137–159
dc.relationLapicque L (1907) Recherches quantitatives sur l’excitation électriquedes nerfs traitée comme une polarisation. J Physiol Pathol Gen9:620–635
dc.relationLee Y et al (1996) A primary acoustic startle reflex pathway: obligatoryrole of cochlear root neurons and the nucleus reticularis pontiscaudalis. J Neurosci 16(11):3775–3789
dc.relationLeitner DS et al (1985) Role of the inferior colliculus in the inhibitionof acoustic startle in the rat. Physiol Behav 34:65–70
dc.relationLeumann L et al (2001) A neural network approach to the acoustic star-tle reflex and prepulse inhibition. Brain Res Bull 56(2):101–110
dc.relationLi L et al (1998) Prepulse inhibition following lesions of the inferiorcolliculus: prepulse intensity functions. Physiol Behav 65:133–139
dc.relationLi L et al (2009) Top-down modulations of prepulse inhibition of thestartle reflex in humans and rats. Neurosci Behav Rev 33:1157–1167
dc.relationNaka KI, Rushton WAH (1966) S-potentials from luminosity units inthe retina of fish (Cyprinidae). J Physiol 185:587–599
dc.relationPlappert C, Pilz P, Schnitzler H (2004) Factors governing prepulse inhi-bition and prepulse facilitation of the acoustic startle response inmice. Behav Brain Res 152:403–412
dc.relationSchmajuk NA et al (2006) Startle and prepulse inhibition as a functionof background noise: a computational and experimental analysis.Behav Brain Res 170:182–196
dc.relationShepherd GM (2004) Introduction to synaptic circuits. In: ShepherdGM (ed) The synaptic organization of the brain, 5th edn. OxfordUniversity Press, Oxford
dc.relationSwerdlow NR, Geyer MA (1993) Prepulse inhibition of acoustic star-tle in rats after lesions of the pedunculopontine tegmental nucleus.Behav Neurosci 107:104–117
dc.relationSwerdlow NR, Caine SB, Braff DL, Geyer MA (1992) The neural sub-strates of sensorimotor gating of the startle reflex: a reviewof recentfindings and their implications. Psychopharmacology 6:176–190
dc.relationSwerdlow NR et al (2001) Neural circuit regulation of prepulse inhibi-tion of startle in the rat: current knowledge and future challenges.Psychopharmacology 156:194–215
dc.relationVogt BA (2005) Pain and emotion interactions in subregions of thecingulated gyrus. Nat Rev Neurosci 6:533–544
dc.relationWilson C (2004) Basal ganglia. In: Shepherd G (ed) The synaptic orga-nization of the brain, 5th edn. Oxford Press, Oxford, pp 361–415
dc.relationWinslow JT, Parr LA, Davis M (2002) Acoustic startle, prepulse inhi-bition, and fear-potentiated startle measured in rhesus monkeys.Biol Psychiatry 51:859–866
dc.relationYeomans JS et al (2006) Midbrain pathways for prepulse inhibitionand startle activation in rats. Neuroscience 142:921–929
dc.relationA computational model for the modulation of the prepulseinhibition of the acoustic startle reflex. En: Biological Cybernetics. Número 106 (2012); páginas169-176
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rightsDerechos Reservados - Universidad Autónoma de Occidente
dc.titleA computational model for the modulation of the prepulseinhibition of the acoustic startle reflex
dc.typeArtículo de revista


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