Expresión del receptor tipo toll 4 en células deciduales estromales humanas asociadas a complicaciones del embarazo

dc.contributorBlanco Muñoz, Osmany
dc.creatorGranados Cuao, Jersson-Luis
dc.date.accessioned2018-11-27T14:44:47Z
dc.date.available2018-11-27T14:44:47Z
dc.date.created2018-11-27T14:44:47Z
dc.date.issued2018-04-09
dc.identifierT 86.18 G716e
dc.identifierhttps://repositorio.udes.edu.co/handle/001/651
dc.description.abstractLa Pre-eclampsia (PE) es una enfermedad multisistémica sin causa conocida que afecta entre el 5-7% de mujeres embarazadas, siendo una de las principales causas de morbilidad y mortalidad materno-fetal en todo el mundo. La asociación entre infección e inflamación es considerada la causa principal de complicaciones como la PE, con aumento de citoquinas favoreciendo la disfunción endotelial en placenta. Las células deciduales estromales (DSC) constituyen el principal componente celular de la decidua y protegen al feto frente a bacterias Gram negativas y señales de peligro que emanan de inflamación severa con o sin infección. A través de la expresión del receptor tipo Toll 4 (TLR4) las DSC regulan la respuesta inmune innata durante la infección. El objetivo fue analizar el comportamiento inmunomodulador in vitro de las DSC a partir de PE. Materiales y métodos: estudio analítico de casos y controles. Las DSC fueron aisladas y cultivadas a partir de tejido placentario, de pacientes con parto vaginal sin complicaciones (control, n=6) y parto por cesárea con pre-eclampsia (PE, n=6). La caracterización fenotípica de las DSC se efectuó mediante análisis por citometría de flujo. La expresión del ARN mensajero del TLR4 se cuantificó por RT-PCR en tiempo real. Finalmente, la determinación de citoquinas se realizó por medio de ELISA a partir de sobrenadantes de cultivos celulares. Resultados: la expresión de antígenos característicos fue similar en las DSC estudiadas (CD10, CD29, CD44, CD73 y CD90). La expresión génica del TLR4, no presentó diferencia significativa (p=0,136). Las DSC control secretaron mayor cantidad de IL-6 (media=3631,7pg/mL) en comparación con las de PE (760pg/mL). La secreción de IL-10 presento diferencia significativa (control=4pg/mL, PE11,2pg/mL). Conclusiones: las DSC control y PE no presentaron diferencias significativas en la expresión del TLR4, se sugiere un papel protector a nivel placentario
dc.description.abstractPre-eclampsia (PE) is a multisystemic disease with no known cause that affects 5-7% of pregnant women, being one of the main causes of maternal-fetal morbidity and mortality worldwide. The association between infection and inflammation is considered the main cause of complications such as PE, with increased cytokines favoring endothelial dysfunction in the placenta. Decidual stromal cells (DSC) constitute the main cellular component of the decidua and protect the fetus against Gram-negative bacteria and warning signs that emanate from severe inflammation with or without infection. Through the expression of Toll-like receptor 4 (TLR4), DSCs regulate the innate immune response during infection. The objective was to analyze the in vitro immunomodulatory behavior of DSCs from PE. Materials and methods: analytical case and control study. The DSCs were isolated and cultured from placental tissue, from patients with uncomplicated vaginal delivery (control, n = 6) and cesarean delivery with pre-eclampsia (PE, n = 6). The phenotypic characterization of the DSC was carried out by means of flow cytometry analysis. The expression of the TLR4 messenger RNA was quantified by RT-PCR in real time. Finally, the determination of cytokines was performed by means of ELISA from supernatants of cell cultures. Results: the expression of characteristic antigens was similar in the DSC studied (CD10, CD29, CD44, CD73 and CD90). Gene expression of TLR4 did not present a significant difference (p = 0.136). Control DSCs secreted a higher amount of IL-6 (mean = 3631.7pg / mL) compared to PE (760pg / mL). The secretion of IL-10 showed significant difference (control = 4pg / mL, PE11.2pg / mL). Conclusions: control DSC and PE did not present significant differences in the expression of the TLR4; a protective role at the placental level is suggested.
dc.languagespa
dc.publisherBucaramanga : Universidad de Santander, 2018
dc.publisherFacultad Ciencias de la Salud
dc.publisherMaestría en Investigación en enfermedades Infecciosas
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dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
dc.rightshttps://creativecommons.org/licenses/by-nc/4.0/
dc.rightsDerechos Reservados - Universidad de Santander, 2018
dc.titleExpresión del receptor tipo toll 4 en células deciduales estromales humanas asociadas a complicaciones del embarazo
dc.typeTrabajo de grado - Maestría


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