Gender differences in cardiac left ventricular mass and function: clinical and experimental observations

dc.creatorEscudero, Eduardo Manuel
dc.creatorOrlowski, Alejandro
dc.creatorDíaz, Alberto Alejandro
dc.creatorPinilla, Oscar Andrés
dc.creatorEnnis, Irene Lucía
dc.creatorAiello, Ernesto Alejandro
dc.date2014
dc.date2019-11-11T15:34:33Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/85323
dc.identifierissn:1897-5593
dc.descriptionBackground: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats. LVM and LVF were evaluated in animals and humans by echocardiography and LVM index (LVMI) was obtained. Results: LVMI, myocyte area and CVF were similar in males and females of 1-month-old rats. LVMI in children was similar in both genders. In contrast, in 6-month-old rats (5 males and 5 females), LVMI (17.7 ± 0.7 mg/mm vs. 10.1 ± 0.2 mg/mm; p < 0.01), and myocyte area (4572.5 ± 72.6 μm2 vs. 3293.85 ± 57.8 μm2, p < 0.01) were higher in male animals without differences in CVF. Men (n = 25) exhibited greater LVMI than women (n = 25) (77.4 ± 3.2 g/m2 vs. 63.3 ± 1.8 g/m2, p < 0.01), whereas the LVF was higher in women (105.9 ± 2.9% vs. 95.3 ± 3.5%, p < 0.01). Conclusions: There is a clear gender-associated impact on LVM with aging in humans and rats. Similar CVF and LVF associated to greater myocyte size and LVM in male rats suggest a process of physiological response. However, the increase in cardiac mass without an associated improved cardiac function in men in comparison to women could likely represent a potential disadvantage in the adaptive response during growth.
dc.descriptionFacultad de Ciencias Médicas
dc.formatapplication/pdf
dc.format53-59
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectCiencias Médicas
dc.subjectCardiac function
dc.subjectCardiac hypertrophy
dc.subjectCardiac myocytes
dc.subjectSex differences
dc.titleGender differences in cardiac left ventricular mass and function: clinical and experimental observations
dc.typeArticulo
dc.typeArticulo


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