Pertussis seroprevalence in adults, post-partum women and umbilical cord blood

Estudio de seroprevalencia de coqueluche en adultos jóvenes, mujeres en puerperio inmediato y sangre del cordón umbilical

dc.creatorFallo, Aurelia
dc.creatorManonelles, Gabriela
dc.creatorHozbor, Daniela Flavia
dc.creatorLara, Claudia
dc.creatorHuespe, Miguel
dc.creatorMazzeo, Silvina
dc.creatorCanle, Oscar
dc.creatorGalas, Marcelo
dc.creatorLópez, Eduardo
dc.date2014
dc.date2019-11-06T14:13:18Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/85042
dc.identifierissn:0325-0075
dc.descriptionPertussis is a vaccine-preventable disease that affects people of all ages. Young adults who have lost their immunity to pertussis are the major source of infection in infants. Given the steady increase of pertussis cases, new prevention strategies are required. Objective. To assess pertussis seroprevalence in adult blood donors, post-partum women, and umbilical cords. Metod. Measurement of total titers of anti-Bordetella spp. (Bordetella) antibodies using an enzyme-linked immunosorbent assay. Serum samples from 103 donors, 101 post-partum women and 100 umbilical cords were analyzed. Titers ≤80 were considered of low impact against the disease. The assessment included transplacental transfer of antibodies and the umbilical cord/maternal ratio of antibody titers. Results. Donors mean age was: 28 ± 6 years old. Median anti-Bordetella titers: 320; interquartile range (IQR):160-320; 10% had titers ≤80. Post-partum women mean age was: 26 ± 6 years old. Median anti-Bordetella titers:160 (IQR:80-320), with titers significantly lower than in female donors (p= 0.00002). Titers ≤80 were found in 30% of post-partum women. Median anti-Bordetella titers in umbilical cords: 160 (IQR: 80-160). Titers ≤80 were more frequently found in umbilical cords than in mothers (44% versus 30%, p= 0.04). Transplacental transfer was 0.83. Umbilical cord titers were equal to maternal titers in 54% of cases, lower in 37%, and higher only in 8%. Conclusion. Titers of anti-Bordetella antibodies in post-partum women were significantly lower than in female blood donors. Titers ≤80 were found in 30% of post-partum women and 44% of umbilical cords. These data may account for the high rates of pertussis in young infants who have not yet completed their vaccination schedule.
dc.descriptionFacultad de Ciencias Exactas
dc.formatapplication/pdf
dc.format315-322
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectBioquímica
dc.subjectPertussis
dc.subjectPrevalence
dc.subjectPrevention and control
dc.titlePertussis seroprevalence in adults, post-partum women and umbilical cord blood
dc.titleEstudio de seroprevalencia de coqueluche en adultos jóvenes, mujeres en puerperio inmediato y sangre del cordón umbilical
dc.typeArticulo
dc.typeArticulo


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