| dc.creator | Aiello, Ernesto Alejandro | |
| dc.creator | Villa Abrille, María Celeste | |
| dc.creator | Cingolani, Horacio Eugenio | |
| dc.date | 2002 | |
| dc.date | 2019-11-01T17:57:45Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/84668 | |
| dc.identifier | issn:0009-7330 | |
| dc.description | The goal of the present study was to evaluate the effects of Ang II on the current produced by the Na<SUP>+</SUP>-Ca<SUP>2+</SUP> exchanger (I<SUB>NCX</SUB>) working in the reverse mode and the possible autocrine role played by the release of endothelin (ET) in these actions. I<SUB>NCX</SUB> was studied in isolation in cat cardiac myocytes. Angiotensin II (Ang II) (100 nmol/L) increased I<SUB>NCX</SUB> at potentials higher than 0 mV (at +60 mV: 2.07±0.22 pA/pF in control versus 2.73±0.22 pA/pF in Ang II, n = 9; P < 0.05). The increase in I<SUB>NCX</SUB> induced by Ang II was prevented by the treatment of the cells with the unspecific blocker of the ET receptors, TAK 044 (1 μmol/L) (at +60 mV: 2.15±0.27 pA/pF in control versus 2.01±0.26 pA/pF in Ang II, n=5, NS). These results show, for the first time, that the effect of Ang II on I<SUB>NCX</SUB> is the result of the autocrine actions of ET released by the octapeptide. | |
| dc.description | Facultad de Ciencias Médicas | |
| dc.description | Centro de Investigaciones Cardiovasculares | |
| dc.format | application/pdf | |
| dc.format | 374-376 | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.rights | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
| dc.subject | Ciencias Médicas | |
| dc.subject | Angiotensin II | |
| dc.subject | Cardiac myocytes | |
| dc.subject | Endothelin | |
| dc.subject | Sodium-calcium exchanger | |
| dc.title | Autocrine stimulation of cardiac Na+-Ca2+ exchanger currents by endogenous endothelin released by angiotensin II | |
| dc.type | Articulo | |
| dc.type | Comunicacion | |
