Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis

dc.creatorRulli, Néstor E.
dc.creatorRolph, Michael S.
dc.creatorSrikiatkhachorn, Anon
dc.creatorAnantapreecha, Surapee
dc.creatorGuglielmotti, Angelo
dc.creatorMahalingam, Suresh
dc.date2011
dc.date2019-10-21T13:58:56Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/83659
dc.identifierissn:0022-1899
dc.descriptionChikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-α, interferon-γ, and monocyte chemotactic protein 1 (MCP-1) were dramatically induced in tissues from infected mice. The same factors were detected in the serum of patients with CHIKV-induced polyarthralgia and polyarthritis, with MCP-1 levels being particularly elevated. Bindarit (MCP inhibitor) treatment ameliorated CHIKV disease in mice. Histological analysis of muscle and joint tissues showed a reduction in inflammatory infiltrate in infectedmice treated with bindarit. These results suggest that bindarit may be useful in treating CHIKV-induced arthritides in humans.
dc.descriptionFacultad de Ciencias Exactas
dc.formatapplication/pdf
dc.format1026-1030
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectCiencias Exactas
dc.subjectCiencias Médicas
dc.subjectChikungunya virus
dc.subjectarthritis
dc.subjectmyositis
dc.titleProtection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis
dc.typeArticulo
dc.typeArticulo


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