| dc.creator | Pérez, Luis Orlando | |
| dc.creator | Abba, Martín Carlos | |
| dc.creator | Dulout, Fernando Noel | |
| dc.creator | Golijow, Carlos Daniel | |
| dc.date | 2006-03-16 | |
| dc.date | 2019-10-15T13:18:09Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/83226 | |
| dc.identifier | issn:1007-9327 | |
| dc.description | <b>Aim:</b> To evaluate the potential association between p53 codon 72 polymorphism and sporadic colorectal adenocarcinoma development, and human papillomavirus (HPV) infection.
<b>Methods:</b> One-hundred and nine controls and 53 patients with colon cancer from the city of La Plata, Argentina were analyzed. p53 codon 72 genotypes and HPV infection were identified using allele-specific polymerase chain reaction and nested polymerase chain reaction, respectively.
<b>Results:</b> The differences in the distribution of p53 codon 72 polymorphism between the cases and controls were statistically significant. The arginine allele had a prevalence of 0.65 in controls and 0.77 in cases. The corresponding odds ratio for the homozygous arginine genotype was 2.08 (95% CI, 1.06-4.05; P<0.05). Lack of association was found between p53 polymorphism and HPV infection in the set of adenocarcinomas.
<b>Conclusion:</b> The findings of the present study indicate that p53 codon 72 arginine homozygous genotype may represent a genetic predisposing factor for colon cancer development. However, further studies are needed in order to elucidate the role of p53 codon 72 polymorphism in colorectal cancer. | |
| dc.description | Facultad de Ciencias Veterinarias | |
| dc.format | application/pdf | |
| dc.format | 1426-1429 | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
| dc.subject | Biología | |
| dc.subject | Colorectal cancer | |
| dc.subject | Human papilomavirus | |
| dc.subject | p53 codon 72 polymorphism | |
| dc.title | Evaluation of p53 codon 72 polymorphism in adenocarcinomas of the colon and rectum in La Plata, Argentina | |
| dc.type | Articulo | |
| dc.type | Articulo | |
