| dc.creator | Laguens, Graciela | |
| dc.creator | Coronato, Silvia | |
| dc.creator | Chambó, Jorge | |
| dc.creator | Di Girolamo, María Teresa Vanda | |
| dc.date | 2012-07 | |
| dc.date | 2019-09-12T15:12:35Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/81072 | |
| dc.identifier | issn:2168-1597 | |
| dc.description | The interaction between some chemokines with tumoral and stromal cells can influence tumor progression. CXCL9, a monokine induced by interferon gamma (MIG), targets lymphocytes. The aim of our study was to identify and quantify CD4+ and CD8+ T cells in the stroma of human breast cancer and correlate them with the presence of MIG/CXCL9. In 58 specimens of human breast carcinoma and 10 normal breast tissue from mammoplasty surgery, immunohistochemis- try and ELISA methods were performed. The number of CD4+ and CD8+ T cells in breast cancer tissue was signifi-cantly increased compared with normal breast tissue with a clear predominance of CD8+ T cells. MIG/CXCL9 levels were significantly elevated respect normal breast tissue. This chemokine correlated with the number of CD8+ T cells only in non-metastatic tumors. These data suggest that MIG targets cytotoxic T cells. Their recruitment into breast car-cinoma can play a critical role in malignant progression, inhibiting the production of metastasis. | |
| dc.description | Facultad de Ciencias Médicas (FCM) | |
| dc.format | application/pdf | |
| dc.format | 7-11 | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
| dc.subject | Ciencias Médicas | |
| dc.subject | Breast Cancer | |
| dc.subject | CD4+ T cells | |
| dc.subject | CD8+ T Cells’ MIG/CXCL9 | |
| dc.subject | Chemokines | |
| dc.title | Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9 | |
| dc.type | Articulo | |
| dc.type | Articulo | |
