dc.date.accessioned2011-03-10T19:52:36Z
dc.date.accessioned2019-05-28T12:10:41Z
dc.date.available2011-03-10T19:52:36Z
dc.date.available2019-05-28T12:10:41Z
dc.date.created2011-03-10T19:52:36Z
dc.date.issued2001-08
dc.identifierROSSONI, L.V.; PINTO, V.D.; VASSALLO, D.V. Effects of small doses of ouabain on the arterial blood pressure of anesthetized hypertensive and normotensive rats. Braz J Med Biol Res, Ribeirão Preto, v. 34, n. 8, p. 1065-1077, ago. 2001. Disponível em: <http://www.scielo.br/pdf/bjmbr/v34n8/3898.pdf>. Acesso em: 7 fev. 2011.
dc.identifier1678-4510
dc.identifierhttp://repositorio.ufes.br/handle/10/605
dc.identifier10.1590/S0100-879X2001000800014
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2867167
dc.description.abstractOuabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The effects of 0.18 and 18 µg/kg, and 1.8 mg/kg ouabain pretreatment on the phenylephrine (PHE; 0.1, 0.25 and 0.5 µg, in bolus)-evoked pressor responses were investigated using anesthetized normotensive (control and uninephrectomized) and hypertensive (1K1C and DOCA-salt treated) rats. Treatment with 18 µg/kg ouabain increased systolic and diastolic blood pressure in all groups studied. However, the magnitude of this increase was larger for the hypertensive 1K1C and DOCA-salt rats than for normotensive animals, while the pressor effect of 0.18 µg/kg ouabain was greater only in DOCA-salt rats. A very large dose (1.8 mg/kg) produced toxic effects on the normotensive control but not on uninephrectomized or 1K1C rats. Rat tail vascular beds were perfused to analyze the effects of 10 nM ouabain on the pressor response to PHE. In all animals, 10 nM ouabain increased the PHE pressor response, but this increase was larger in hypertensive DOCA-salt rats than in normotensive and 1K1C rats. Results suggested that a) increases in diastolic blood pressure induced by 18 µg/kg ouabain were larger in hypertensive than normotensive rats; b) in DOCA-salt rats, smaller ouabain doses had a stronger effect than in other groups; c) hypertensive and uninephrectomized rats were less sensitive to toxic doses of ouabain, and d) after treatment with 10 nM ouabain isolated tail vascular beds from DOCA-salt rats were more sensitive to the pressor effect of PHE than those from normotensive and 1K1C hypertensive rats. These data suggest that very small doses of ouabain, which might produce nanomolar plasma concentrations, enhance pressor reactivity in DOCA-salt hypertensive rats, supporting the idea that endogenous ouabain may contribute to the increase and maintenance of vascular tone in hypertension.
dc.languageeng
dc.rightsopen access
dc.subjectOuabaína
dc.subjectPressão arterial
dc.subjectFenilefrina
dc.subjectDesoxicorticosterona
dc.subjectRatos Wistar
dc.subjectHipertensão renovascular
dc.subjectOuabain
dc.subjectBlood Pressure
dc.subjectPhenylephrine
dc.subjectHypertension, Renovascular
dc.subjectDesoxycorticosterone
dc.subjectRats, Wistar
dc.subjectPressor reactivity
dc.subjectUninephrectomy
dc.titleEffects of small doses of ouabain on the arterial blood pressure of anesthetized hypertensive and normotensive rats
dc.typeArtículos de revistas


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