| dc.creator | Santos, María Rita | |
| dc.creator | Ramallo, Virginia | |
| dc.creator | Muzzio, Marina | |
| dc.creator | López Camelo, Jorge Santiago | |
| dc.creator | Bailliet, Graciela | |
| dc.date | 2015 | |
| dc.date.accessioned | 2019-05-28T11:36:06Z | |
| dc.date.available | 2019-05-28T11:36:06Z | |
| dc.identifier | http://digital.cic.gba.gob.ar/handle/11746/2336 | |
| dc.identifier | Documento completo | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/2864289 | |
| dc.description | <strong>Background:</strong> NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines, hydrazine drugs, and a great number of toxins and carcinogens present in diet, cigarette smoke, and environment. Aim: To determine the association between alleles determining slow acetylator phenotype and the risk of NSCLP.<strong> Material and methods:</strong> We analyzed *5 (481C>T), *6 (590G>A) and *7 (857G>A) alleles which determine the slow acetylator phenotype and *4 (wild type) allele by polymerase chain reaction/restriction fragment length polymorphism in 97 progenitor-case trios of NSCLP in Argentinian Obstetric Wards. We evaluated the transmission disequilibrium (TDT). Results: TDT showed a positive association between allele *5 and NSCLP (odds ratio=1.6; p=0.03). Conclusions: The presence of *5 allele is significantly higher in cases with congenital NSCLP. | |
| dc.format | application/pdf | |
| dc.format | p. 444-450 | |
| dc.language | Español | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | Attribution 4.0 International (BY 4.0) | |
| dc.subject | Genética Humana | |
| dc.subject | Odontología, Medicina y Cirugía Oral | |
| dc.title | Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina | |
