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        Neonatal androgenization-induced early endocrine metabolic and ovary misprogramming in the female rat

        Registro en:
        http://digital.cic.gba.gob.ar/handle/11746/4215
        http://repositorioslatinoamericanos.uchile.cl/handle/2250/2863220
        Autor
        Ongaro, Luisina
        Salvetti, N.
        Giovambattista, Andrés
        Spinedi, E.
        Ortega, H.
        Institución
        • Comisión de Investigaciones Científicas (Argentina)
        Resumen
        Aim: Androgen excess predisposes the organism to develop metabolic-endocrine and reproductive dysfunctions, among them the development of a phenotype resembling that ofhumanPolycystic Ovary Syndrome(PCOS).<u>METHODS</u>: We analyzed the impact of a single neonatal (5day-old)testosterone propionate(TP; s.c. 1.25mg/female pup) dose on: a) several metabolic-endocrine activities and b) ovarian steroidogenic and granulosacell(GC) functions and also follicular population in juvenile and adult TP and control (CT)rats. <u>Key Findings</u>: Compared to CTrats, TPanimalswere characterized by: a) acceleratedgrowth, hyperadiposity and hyperleptinemia, b) very early (pre-weaning age) vaginal opening, c)hyperinsulinemiain adult life, d) dysfunctional ovariansteroidogenesis, e) conserved GC functionality in both juveniles (in vitro) and adults (in vivo), and f)estrous cyclesarrested atestrus. Finally, histological studies of the ovaries indicated that in TP (vs. CT)rats: i) primary and antral follicle frequencies were 3- and 15-fold higher and lower, respectively, in juveniles and ii) secondary and atretic follicle frequencies were 3- and 5-fold lower and higher, respectively, in adults. Large cystic images without corpus luteum were observed in the ovaries from adult TPratsonly. <u>Significance</u>: Our results strongly suggest that transient neonatal hyperandrogenemia induced early misprogramming of metabolic-endocrine and ovarian (steroidogenesis/folliculogenesis) functions. Conversely, TPratspreserved their ovary GC endocrine function. Our results further support the high risk of developingovarian hyperstimulation syndromeforinfertilewomen with transient/chronic hyperandrogenemia (PCOS) subjected to assisted reproductive technologies.
        Materias
        Ciencias Biológicas

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        Red de Repositorios Latinoamericanos
        + de 8.000.000 publicaciones disponibles
        500 instituciones participantes
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Ingreso Administradores
        Colecciones destacadas
        • Tesis latinoamericanas
        • Tesis argentinas
        • Tesis chilenas
        • Tesis peruanas
        Nuevas incorporaciones
        • Argentina
        • Brasil
        • Colombia
        • México
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018