dc.creatorCastrogiovanni, Daniel
dc.creatorOngaro, Luisina
dc.creatorZuburía, Guillermina
dc.creatorGiovambattista, Andrés
dc.creatorSpinedi, Eduardo
dc.date2015
dc.date.accessioned2019-05-28T11:17:15Z
dc.date.available2019-05-28T11:17:15Z
dc.identifierhttp://digital.cic.gba.gob.ar/handle/11746/2273
dc.identifierDocumento completo
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2860760
dc.descriptionRats neonatally treated with monosodium L-glutamate (MSG) are deeply dysfunctional in adulthood. We explored the effect of an oral low dose of metformin treatment in male MSG rats on adipoinsular axis and visceral adipose tissue (VAT) dysfunctions, in both basal (nonfasting) and endotoxemia conditions. MSG rats, treated or not treated with metformin (30 days prior to experimentation), and control litter-mates (CTR) were studied at 90 days of age. Peripheral concentrations of glucose, lipids, and hormones were determined in basal and post-lipopolysaccharide (LPS) treatment conditions. Food intake and body weight (BW) were recorded and VAT mass and leptin mRNA levels were evaluated. Data indicated that MSG rats were lighter and displayed hypercorticosteronemia, hypophagia, adipoinsular axis hyperactivity, and enhanced VAT mass associated with an increased leptin gene expression. Interestingly, metformin-treated MSG rats corrected BW catch-up and counteracted VAT (mass and leptin mRNA level) and adipoinsular axis (basal and post-LPS) dysfunctions. Thus metformin treatment in MSG rats is able to correct several VAT and metabolic-endocrine dysfunctions. Our study suggests that a low-dose metformin therapy is effective to correct, at least in part, adipoinsular axis dysfunction in hypertrophic obese phenotypes, such as that of the human Cushing syndrome.
dc.formatapplication/pdf
dc.format9 p.
dc.languageInglés
dc.publisherHindawi Publishing Corporation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International (BY 4.0)
dc.subjectBiología Celular, Microbiología
dc.titleOral Metformin Treatment Counteracts Adipo-Insular Axis Dysfunction in Hypothalamic Obese Rats


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