| dc.creator | Mercer, Natalia | |
| dc.creator | Ahmed, Hafiz | |
| dc.creator | Etcheverry, Susana B. | |
| dc.creator | Vasta, Gerardo R. | |
| dc.creator | Cortizo, Ana María | |
| dc.date | 2007 | |
| dc.date.accessioned | 2019-05-28T11:04:15Z | |
| dc.date.available | 2019-05-28T11:04:15Z | |
| dc.identifier | http://digital.cic.gba.gob.ar/handle/11746/4960 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/2858368 | |
| dc.description | Advanced glycation end products (AGEs) have been proposed as the pathological mechanisms underlying diabetic chronic complications. They may also play a role in the pathogenesis of diabetic osteopenia, although their mechanisms of action remain unclear. We investigated the protein (immunofluorescence) and gene expression (realtime RT-PCR) of two receptors for AGEs, RAGE and galectin-3, as well as their regulation by AGEs, and the apoptotic effect on osteoblast-like cells (UMR106 and MC3T3E1) in culture. AGEs up-regulated the expression of RAGE and galectin-3 in both cells lines. These effects were accompanied by an increase in the corresponding mRNA in the non-tumoral MC3T3E1 but not in the osteosarcoma UMR106 cells. Finally, we demonstrated that a 24 h exposure to AGEs induced apoptosis in both cell lines. Thus, AGEs-receptors may play important roles in the bone alterations described in aging and diabetic patients. | |
| dc.format | application/pdf | |
| dc.format | 8 p. | |
| dc.language | Inglés | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | Attribution 4.0 International (BY 4.0) | |
| dc.subject | Ciencias Químicas | |
| dc.title | Regulation of advanced glycation end product (AGE) receptors and apoptosis by AGEs in osteoblast-like cells | |
