dc.contributorCobre, Juliana
dc.contributorhttp://lattes.cnpq.br/1042802390444616
dc.contributorhttp://lattes.cnpq.br/6574049419922178
dc.creatorMarins, Bruna Aparecida Barbosa
dc.date.accessioned2018-12-04T12:20:51Z
dc.date.available2018-12-04T12:20:51Z
dc.date.created2018-12-04T12:20:51Z
dc.date.issued2018-10-03
dc.identifierMARINS, Bruna Aparecida Barbosa. Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos. 2018. Dissertação (Mestrado em Estatística) – Universidade Federal de São Carlos, São Carlos, 2018. Disponível em: https://repositorio.ufscar.br/handle/ufscar/10754.
dc.identifierhttps://repositorio.ufscar.br/handle/ufscar/10754
dc.description.abstractEscalation with overdose control proportional hazards is a Bayesian method with overdose control that estimates the maximum tolerated dose (MTD) assuming that the time a patient takes to show toxicity follows the proportional hazards model. In this work, we analyse the consequences of adopting a method based on the proportional hazard model when the time until toxicity follows the proportional survival model. In order to seek to answer if we would have an overestimate or an underestimate of MTD, simulations were performed in which we considered proportional odds survival data and application of the EWOC-PH method. As an extension of the EWOC-PH method, we propose the EWOC-POS method which assumes that time until toxicity follows the proportional odds survival model.
dc.languagepor
dc.publisherUniversidade Federal de São Carlos
dc.publisherUFSCar
dc.publisherPrograma Interinstitucional de Pós-Graduação em Estatística - PIPGEs
dc.publisherCâmpus São Carlos
dc.rightsAcesso aberto
dc.subjectChances de sobrevivências proporcionais
dc.subjectControle de overdose
dc.subjectDose máxima tolerada
dc.subjectRiscos proporcionais
dc.subjectMaximum tolerated dose
dc.subjectOverdose control
dc.subjectProportional odds survival
dc.subjectProportional hazards
dc.titleEstudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos
dc.typeTesis


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