dc.contributorSchpector, Júlio Zukerman
dc.contributorhttp://lattes.cnpq.br/4252331837170383
dc.contributorhttp://lattes.cnpq.br/6352410919556062
dc.creatorDelling, Felix Nicolai
dc.date.accessioned2018-06-25T20:03:06Z
dc.date.available2018-06-25T20:03:06Z
dc.date.created2018-06-25T20:03:06Z
dc.date.issued2016-02-29
dc.identifierDELLING, Felix Nicolai. Síntese, caracterização de cocristais e sais-cocristais de ingredientes farmacêuticos ativos. 2016. Tese (Doutorado em Química) – Universidade Federal de São Carlos, São Carlos, 2016. Disponível em: https://repositorio.ufscar.br/handle/ufscar/10216.
dc.identifierhttps://repositorio.ufscar.br/handle/ufscar/10216
dc.description.abstractUsing techniques/procedures of green chemistry, solid state grinding, solvent drop grinding and solvent drop grinding with heating, twenty compounds were synthesized. Eleven compounds of dropropizine (antitussive): two co-crystals and nine co-crystal salts, nine compounds of carbamazepine (anticonvulsant and mood stabilizer) were synthesized: eigth channel compounds and a possible co-crystal. The sulfamethoxazole (bactericidal) showed not to be a good choice as no new compounds could be synthesized in the reaction conditions used for all experiments, only its hemihydrate could be obtained. The compounds were characterized by powder X-ray diffraction, infrared spectroscopy, differential scanning calorimetry, mass spectrometry and single crystal X-ray diffraction methods. Using infrared spectroscopy it was possible to identify four characteristic vibrational modes for the salts, i.e. two vibrational modes of the COO- species (~1540 and ~1358 cm-1) and two of the N+–H species (~1385 and ~1258 cm-1). For the co-crystals the characteristic stretch of the carboxylic acids, at ~1700cm-1, did not disappear. The crystal, molecular and packing structures of two compounds, i.e. of the sulfamethoxazole hemihydrate and of the salt of dropropizine with 4-hydroxybenzoic acid, were determined by single crystal X-ray diffraction. Mechanisms were proposed for the solid state grinding and solvent drop grinding with heating reactions. Finally, a proton transfer mechanism was proposed for the solid state grinding and solvent drop grinding with heating to synthesize a salt.
dc.languagepor
dc.publisherUniversidade Federal de São Carlos
dc.publisherUFSCar
dc.publisherPrograma de Pós-Graduação em Química - PPGQ
dc.publisherCâmpus São Carlos
dc.rightsAcesso aberto
dc.subjectQuímica inorgânica
dc.subjectSíntese
dc.subjectChemistry, Inorganic
dc.subjectSynthesis
dc.titleSíntese, caracterização de cocristais e sais-cocristais de ingredientes farmacêuticos ativos
dc.typeTesis


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