dc.contributor | Schpector, Júlio Zukerman | |
dc.contributor | http://lattes.cnpq.br/4252331837170383 | |
dc.contributor | http://lattes.cnpq.br/6352410919556062 | |
dc.creator | Delling, Felix Nicolai | |
dc.date.accessioned | 2018-06-25T20:03:06Z | |
dc.date.available | 2018-06-25T20:03:06Z | |
dc.date.created | 2018-06-25T20:03:06Z | |
dc.date.issued | 2016-02-29 | |
dc.identifier | DELLING, Felix Nicolai. Síntese, caracterização de cocristais e sais-cocristais de ingredientes farmacêuticos ativos. 2016. Tese (Doutorado em Química) – Universidade Federal de São Carlos, São Carlos, 2016. Disponível em: https://repositorio.ufscar.br/handle/ufscar/10216. | |
dc.identifier | https://repositorio.ufscar.br/handle/ufscar/10216 | |
dc.description.abstract | Using techniques/procedures of green chemistry, solid state grinding,
solvent drop grinding and solvent drop grinding with heating, twenty compounds were
synthesized. Eleven compounds of dropropizine (antitussive): two co-crystals and
nine co-crystal salts, nine compounds of carbamazepine (anticonvulsant and mood
stabilizer) were synthesized: eigth channel compounds and a possible co-crystal.
The sulfamethoxazole (bactericidal) showed not to be a good choice as no new
compounds could be synthesized in the reaction conditions used for all experiments,
only its hemihydrate could be obtained. The compounds were characterized by
powder X-ray diffraction, infrared spectroscopy, differential scanning calorimetry,
mass spectrometry and single crystal X-ray diffraction methods. Using infrared
spectroscopy it was possible to identify four characteristic vibrational modes for the
salts, i.e. two vibrational modes of the COO- species (~1540 and ~1358 cm-1) and
two of the N+–H species (~1385 and ~1258 cm-1). For the co-crystals the
characteristic stretch of the carboxylic acids, at ~1700cm-1, did not disappear. The
crystal, molecular and packing structures of two compounds, i.e. of the
sulfamethoxazole hemihydrate and of the salt of dropropizine with 4-hydroxybenzoic
acid, were determined by single crystal X-ray diffraction. Mechanisms were proposed
for the solid state grinding and solvent drop grinding with heating reactions. Finally, a
proton transfer mechanism was proposed for the solid state grinding and solvent
drop grinding with heating to synthesize a salt. | |
dc.language | por | |
dc.publisher | Universidade Federal de São Carlos | |
dc.publisher | UFSCar | |
dc.publisher | Programa de Pós-Graduação em Química - PPGQ | |
dc.publisher | Câmpus São Carlos | |
dc.rights | Acesso aberto | |
dc.subject | Química inorgânica | |
dc.subject | Síntese | |
dc.subject | Chemistry, Inorganic | |
dc.subject | Synthesis | |
dc.title | Síntese, caracterização de cocristais e sais-cocristais de ingredientes farmacêuticos ativos | |
dc.type | Tesis | |