Artículos de revistas
Is disorganized schizophrenia a predictor of treatment resistance? Evidence from an observational study
Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 35, n. 4, p. 432-434, 2013.
Ortiz, Bruno Bertolucci
Araujo Filho, Gerardo Maria de
Bressan, Rodrigo Affonseca
Objective: To investigate whether inpatients with disorganized schizophrenia are more resistant to treatment. Method: Eighty-five inpatients were assessed at admission and at discharge for schizophrenia subtype, symptom severity, and treatment resistance criteria. Results: Disorganized patients were significantly more treatment-resistant than paranoid patients (60%, p = 0.001), and presented worse scores on the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression Scale (CGI-S), and the Global Assessment of Functioning Scale (GAF) (p < 0.001). Although the difference was not significant, 80% of treatment-resistant patients with disorganized schizophrenia responded to clozapine. Conclusion: Patients with the disorganized subtype of schizophrenia should benefit from clozapine as a second-line agent.